Tosca Holtrop

PHD Candidate - OIO

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Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses Tosca Holtrop, Arianne M Brandsma, Louris J Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M Passchier, Maaike Nederend, J H Marco Jansen, Anouk G van Mourik, Rolf T Urbanus, Diane van der Woude, Roger E G Schutgens, Rene E M Toes, Bert J C Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H W Leusen
Nature Communications, 2025, vol. 16

Extracellular domain 1 of human FcγRI (CD64) identified as the binding site for anti-FcγRI antibodies Tosca Holtrop, Elsemieke M Passchier, Sophie O'Toole, W Joost Kraan, Kevin Budding, Jeanette H W Leusen
mAbs, 2025, vol. 17

Combining Cellular Immunization and Phage Display Screening Results in Novel, FcγRI-Specific Antibodies Steffen Krohn, Tosca Holtrop, Arianne M Brandsma, Petra Moerer, Maaike Nederend, Nikos Darzentas, Monika Brüggemann, Katja Klausz, Jeanette H W Leusen, Matthias Peipp
Viruses, 2024, vol. 16

Lipopolysaccharide-induced hypothalamic inflammation in cancer cachexia-anorexia is amplified by tumour-derived prostaglandin E2 Xiaolin Li, Tosca Holtrop, Fleur A.C. Jansen, Brennan Olson, Pete Levasseur, Xinxia Zhu, Mieke Poland, Winni Schalwijk, Renger F. Witkamp, Daniel L. Marks, Klaske van Norren
Journal of Cachexia, Sarcopenia and Muscle, 2022, vol. 13, p.3014-3027

Targeting the high affinity receptor, FcγRI, in autoimmune disease, neuropathy, and cancer Tosca Holtrop, Kevin Budding, Arianne M Brandsma, Jeanette H W Leusen
Immunotherapy Advances, 2022, vol. 2