Profile photo Tolboom

Tolboom

Assistant Professor - medical

Strategic program(s):

Biography

Nuclear medicine physician,
Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht and Princess Maxima Centre for pediatric oncology, Utrecht (fixed term).

Specific clinical fields of interest:
Nuclear Neuro-imaging (i.e. neuro-oncology, epilepsy, neurodegeneration), Pediatric nuclear imaging, Hemato-oncology, Head and Neck oncology, Nuclear therapies (theranostics)

Research line: 
Clinical neuro imaging (co-PI of multicenter study using FET PET for management of glioblastoma, local PI of multicenter TAU PET study investigating clinical value of TAU PET in neurodegeneration), national PI for an European Organization for Research and Treatment of Cancer (EORTC) initiated nuclear treatment study in Meningioma (‘LUMEN’ study). Experimental neuroimaging using neuroinflammation tracers (PI of multi-center study using neuroinflammation PET).

Leadership:
-Member and vice chair of EORTC Brain tumour group/ nuclear medicine committee.
-Member of Neuroimaging committee, European Association of Nuclear Medicine (EANM)
-EANM representative for the European Academy of Neurology (EAN), member of management group of EAN scientific panel on neuroimaging.
-EANM liaison person to the EAN Brain Health Summit initiative.
-Co-Chair of Dutch Society for Nuclear Medicine Neuroimaging committee.

Research groups

Nuclear theranostics research

Research aim

With nuclear theranostics we aim to develop radiopharmaceuticals to improve the disease diagnosis and therapy, including clinical translation for direct impact. Disease areas of interest are (childhood) cancer, neurology and infectious diseases.

Go to group

Clinical and translational neuro-oncology

Research aim

We aim to improve treatments and clinical outcomes of patients with gliomas and other brain tumors, by combining expertise from oncobiology, neuropsychology, imaging, surgical & clinical neurology, and palliative care.

Go to group

Recent publications

Drawing parallels between amyloid PET in Alzheimer’s disease and amino acid PET in primary and secondary brain tumors Nelleke Tolboom, Antoine Verger, Matthias Preusser, Marjolein Geurts, Philip Scheltens, Nathalie Lisa Albert
Neuro-oncology advances, 2026, vol. 8
Efficacy of Intra-arterial [177Lu]Lu-DOTATATE monotherapy for treatment-refractory meningioma A. El Ghalbouni, T. J. Snijders, A. Amerein, N. Tolboom, M. Patt, C. J. Maurer, I. C. van der Schaaf, C. Lapa, A. J.A.T. Braat
Journal of Neuro-Oncology, 2026, vol. 176, p.1-9
EANM perspective on clinical PET and SPECT imaging in schizophrenia-spectrum disorders Antoine Rogeau, Anne Jetske Boer, Eric Guedj, Arianna Sala, Iris E. Sommer, Mattia Veronese, Monique van der Weijden-Germann, Nelleke Tolboom, Henryk Barthel, Tatjana Traub-Weidinger, Igor Yakushev, Matthias Brendel, Nathalie L. Albert, Antoine Verger, Diego Cecchin, Donatienne Van Weehaeghe, Francesco Fraioli,
European Journal of Nuclear Medicine and Molecular Imaging, 2025, vol. 52, p.876-899
From Compassionate Use Toward High-Level Evidence for Radiopharmaceutical Therapy in Recurrent Meningioma Nelleke Tolboom, Nathalie L Albert, Arthur J A T Braat, Tom J Snijders, Emeline Tabouret, Luc Taillandier, Matthias Brendel, Diego Cecchin, Pablo Aguiar-Fernandez, Francesco Fraioli, Eric Guedj, Tatjana Traub-Weidinger, Igor Yakushev, Donatienne Van Weehaeghe, Matthias Preusser, Antoine Verger
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025
Imaging findings in paediatric non-Hodgkin lymphoma Ivana Dasic, Annemieke S Littooij, Nelleke Tolboom, Jan L C M Loeffen, Polina Pavicevic, Jelena Lazic, Rutger A J Nievelstein
Pediatric radiology, 2025, vol. 56, p.57-77
Varying Levels of Inflammatory Activity in Brain and Body of Patients with Persistent Fatigue and Difficulty Concentrating After COVID-19 Denise Visser, Sandeep S V Golla, Xavier Palard-Novello, Sander C J Verfaillie, Anouk Verveen, Dook W Koch, Roos M Rikken, Elsmarieke van de Giessen, Pythia T Nieuwkerk, Marijke E den Hollander, Janneke Horn, Caroline M van Heugten, Menno D de Jong, Cees C van den Wijngaard, Tessa van der Maaden, Yvonne M G van Os, Maria Prins, Johanna M A Visser-Meily, Patrick Schober, Robert C Schuit, Michael Kassiou, Albert D Windhorst, Sara Biere-Rafi, Brent Appelman, Michele van Vugt, Frederik Barkhof, Bart N M van Berckel, Ronald Boellaard, Hans Knoop, Nelleke Tolboom
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025, vol. 66, p.1787-1794