Researchers Stefan Nierkens

Stefan Nierkens

Associate Professor

Strategic program(s):

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

Strategic program(s):

Contact

snierken@umcutrecht.nl

Pure profile

Research groups

Pediatric tumor immunology

Research aim

We strive to improve efficacy and safety of immune therapy against pediatric cancers, specifically focussing on the function of immune cells in children undergoing hematopoietic cell transplantation or receiving CAR-T cells.

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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.

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Recent publications

All publications

Effect of clofarabine and fludarabine exposure on outcome after pediatric allogeneic hematopoietic cell transplantation Linde Dekker, Coco de Koning, Laura Nijstad, Kim van der Elst, Rick Admiraal, Birgitta Versluijs, Jaap-Jan Boelens, Alwin Huitema, Caroline Lindemans, Stefan Nierkens
Blood Neoplasia, 2024, vol. 1

Definitions matter Konradin F. Müskens, Winny N.R. Collot-d'Escury, Rana Dandis, Saskia Haitjema, Jürgen Kuball, Moniek A. de Witte, Marc Bierings, Caroline A. Lindemans, Stefan Nierkens, Mirjam E. Belderbos
Hemasphere, 2024, vol. 8

Clinical and Biological Concepts for Mastering Immune Reconstitution After Hematopoietic Cell Transplantation Jürgen Kuball, Raffaella Greco, Stefan Nierkens, Jaap Jan Boelens
2024, p.85-96

Pharmacokinetics and Pharmacodynamics of Systemic Corticosteroids in Autoimmune and Inflammatory Diseases Julia E. Möhlmann, Solaiman Ezzafzafi, Caroline A. Lindemans, Marc H.A. Jansen, Stefan Nierkens, Alwin D.R. Huitema, Matthijs van Luin
Clinical Pharmacokinetics, 2024, vol. 63, p.1251-1270

Corrigendum J. I. Meesters-Ensing, R. Admiraal, L. Ebskamp, A. Lacna, J. J. Boelens, C. A. Lindemans, S. Nierkens
Frontiers in Pharmacology, 2024, vol. 15

A multidimensional analysis reveals distinct immune phenotypes and the composition of immune aggregates in pediatric acute myeloid leukemia Joost B. Koedijk, Inge van der Werf, Livius Penter, Marijn A. Vermeulen, Farnaz Barneh, Alicia Perzolli, Joyce I. Meesters-Ensing, Dennis S. Metselaar, Thanasis Margaritis, Marta Fiocco, Hester A. de Groot-Kruseman, Rubina Moeniralam, Kristina Bang Christensen, Billie Porter, Kathleen Pfaff, Jacqueline S. Garcia, Scott J. Rodig, Catherine J. Wu, Henrik Hasle, Stefan Nierkens, Mirjam E. Belderbos, C. Michel Zwaan, Olaf Heidenreich
Leukemia, 2024, vol. 38, p.2332-2343

Fellowships & Awards

KWF fellowship

Kika

ZonMW-TAS

VillaJoep

Ammodo

External positions

Medische Immunologie - Overeenkomstige taken als Medisch Immunoloog bij LTI UMCU - Prinses Maxima Centrum voor Kinderoncologie

commissie - expertise medische immunologie - NVVI