Profile photo Stefan Nierkens

Stefan Nierkens

Associate Professor

Strategic program(s):

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

 

Research groups

Pediatric tumor immunology

Research aim

We strive to improve efficacy and safety of immune therapy against pediatric cancers, specifically focussing on the function of immune cells in children undergoing hematopoietic cell transplantation or receiving CAR-T cells.

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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.

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Recent publications

Umbilical Cord Blood and Nonengrafting Allogeneic Cell Therapies Robert F. Wynn, Nathan Jeffreys, Stefan Nierkens
Journal of Clinical Oncology, 2026, vol. 44, p.1957-1961
T-cell responses to primary SARS-CoV-2 vaccination in Down syndrome–From childhood to adulthood Lobke C.M. Hensen, Bianca M.M. Streng, Femke van Wijk, Stefan Nierkens, Joanne G. Wildenbeest, Louis J. Bont, Eveline M. Delemarre,
Human Vaccines and Immunotherapeutics, 2026, vol. 22
Diagnosis of primary CNS lymphoma through molecular and immune biomarkers in cerebrospinal fluid (PRICELUS) Josephus L M van Rooij, Peter H Wessels, Johanna M Niers, Jacoline E C Bromberg, Johanna M M Gijtenbeek, Rick van Haastert, Henk J T Ruven, Bob Meek, Marcel M Verbeek, Nienke Solleveld-Westerink, Wendy W J de Leng, Angelika Mühlebner, Anton W Langerak, Sharon Berendsen, Edward F Knol, Hanna van Alkemade, Tatjana Seute, Monique C Minnema, Stefan Nierkens, Tom J Snijders
The Lancet. Haematology, 2026, vol. 13, p.e376-e385
Boosting CAR T cell functionality with oncolytic viruses for the treatment of pediatric diffuse midline gliomas Konstantinos Vazaios, Antonio C. Tallon-Cobos, Louisa P.J. van Oosterhout, Piotr Waranecki, Annelisa M. Cornel, Noël M.M. Dautzenberg, Marliek van Hoesel, Caitlyn Forbes, Stefan Nierkens, Vera Kemp, Rob C. Hoeben, Jasper van der Lugt, Friso G. Calkoen, Esther Hulleman
Molecular Therapy Oncology, 2026, vol. 34
Natural SARS-CoV-2 infection in farmed minks (Neovison vison) causes lung pathology, systemic viral spread, and transmission risk, even in asymptomatic animals Sandra Vreman, Giuseppe Giglia, Robert-Jan Molenaar, Renate Hakze-van der Honing, Eveline M Delemarre, Stefan Nierkens, Katrin E Wiese, Gianfilippo Agliani, Wim van der Poel, Frank van Kuppeveld, Berend Jan Bosch, Erwin de Bruin, Andrea Gröne, Naomi de Bruijn, Judith M A van den Brand
Frontiers in veterinary science, 2026, vol. 13
Author Correction Thomas Kimman, Marta Cuenca, Ralph G Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D Meringa, Wendy Boschloo, Douwe M T Bosma, Sanne Kroos, Vania Lo Presti, Joost P G Sluijter, Stefan Nierkens, Niels Bovenschen, Jürgen Kuball, Alain van Mil, Monique C Minnema, Zsolt Sebestyén, Victor Peperzak
Nature Communications, 2026, vol. 17

Fellowships & Awards

KWF fellowship

Kika

ZonMW-TAS

VillaJoep

Ammodo

External positions

Medische Immunologie - Overeenkomstige taken als Medisch Immunoloog bij LTI UMCU - Prinses Maxima Centrum voor Kinderoncologie

commissie - expertise medische immunologie - NVVI