Profile photo Slooter

Slooter

Full Professor

Strategic program(s):

Biography

Arjen Slooter studied Medicine at the Vrije Universiteit, Amsterdam and worked subsequently as a resident in Neurology in Sint Lucas Hospital, Amsterdam (1994). He was research fellow in Neuro-Epidemiology at the G.H. Sergievsky Center, Columbia University, New York (1996), and received a PhD in Epidemiology from Erasmus University, Rotterdam (1998), on a thesis on dementia. During his residency in Neurology at UMC Utrecht (1999-2004), he became enthusiastic for Neurocritical Care. After a fellowship in Intensive Care Medicine (AMC Amsterdam, 2004-2006), he rejoined UMC Utrecht where he worked until 2022 as a consultant neurologist-intensivist at the Department of Intensive Care Medicine. In 2016, he was appointed as Professor of Intensive Care Neuropsychiatry at Utrecht University. Dr Slooter was chair of the delirium section of the (American) Society of Critical Care Medicine (SCCM) guidelines on pain, agitation/sedation, delirium, immobility, and sleep disruption, as well as initiator and chair of an international consortium to update nomenclature on delirium and acute encephalopathy. From 2018 to 2023 he was President of the European Delirium Association. In 2022, he made a career shift to psychiatry.

The research focus of Arjen Slooter is on delirium and on neuropsychiatric outcome after anesthesia/surgery or critical illness. Using various methods and approaches (epidemiology, EEG, MRI), he has investigated all aspects of delirium, including its phenomenology and brain network characteristics, detection and monitoring, risk factors, prognosis, prevention and treatment. Research on neuropsychiatric outcomes includes ICU-related risk factor analyses on cognitive decline, mental illness and chronic pain after critical illness and treatment in the ICU. Arjen lives with his wife Barbara, daughter Pien and son Bas in beautiful Utrecht.

Most recent key publications

1. Van den Boogaard M, Slooter AJC, Brüggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P; REDUCE Study Investigators. Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA 2018;319:680-90. Impact Factor (IF) 157. 

2. Numan T, van den Boogaard M, Kamper AM, Rood PJT, Peelen LM, Slooter AJC; Dutch Delirium Detection Study Group. Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study. Br J Anaesth 2019;122:60-8. IF 9.9.

3. Slooter AJC, Otte WM, Devlin JW, Arora RC, Bleck TP, Claassen J, Duprey MS, Ely EW, Kaplan PW, Latronico N, Morandi A, Neufeld KJ, Sharshar T, MacLullich AMJ, Stevens RD. Updated nomenclature of delirium and acute encephalopathy: statement of ten societies. Intensive Care Med 2020;46:1020-2. IF 42.

4. Wilson JE, Mart M, Cunningham C, Shehabi Y, Girard T, MacLullich A, Slooter AJC, EW Ely. Delirium. Nature Rev Dis Primers 2020;6:90. IF 52. 

5. Duprey MS, Dijkstra-Kersten SMA, Zaal IJ, Briesacher BA, Saczynski JS, Griffith JL, Devlin JW, Slooter AJC. Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain. Am J Respir Crit Care Med 2021;204:566-72. IF 30.5. 

Strategic program(s):

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Research groups

Brain at risk

Research aim

The general aim of our research group is to decrease the burden of delirium during hospital admission and to improve outcome thereafter. Delirium is a frequent and serious complication that increases the risk of dementia.

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Recent publications

Single-channel qEEG characteristics distinguish delirium from no delirium, but not postoperative from non-postoperative delirium D Y Lodema, F L Ditzel, S C A Hut, E van Dellen, W M Otte, A J C Slooter
Clinical Neurophysiology, 2024, vol. 161, p.93-100
Prevalence and trajectories of neuropsychological post-COVID-19 symptoms in initially hospitalized patients Simona Klinkhammer, Annelien A Duits, Janneke Horn, Arjen J C Slooter, Esmée Verwijk, Susanne Van Santen, Johanna M A Visser-Meily, Caroline Van Heugten
Journal of rehabilitation medicine, 2024, vol. 56, p.1-10
Perioperative Levels of IL8 and IL18, but not IL6, are Associated with Nucleus Basalis Magnocellularis Atrophy Three Months after Surgery Maria Heinrich, Claudia Spies, Friedrich Borchers, Insa Feinkohl, Tobias Pischon, Arjen J C Slooter, Clarissa von Haefen, Norman Zacharias, Georg Winterer, Florian Lammers-Lietz
Journal of Neuroimmune Pharmacology, 2024, vol. 19, p.1-17
How to manage catatonia, Parkinson and dementia in ICU David Attali, Charlotte Calligaris, David Grabli, Arjen J C Slooter
Current Opinion in Critical Care, 2024, vol. 30, p.151-156
The Delphi Delirium Management Algorithms Thomas H Ottens, Carsten Hermes, Valerie Page, Mark Oldham, Rakesh Arora, O Joseph Bienvenu, Mark van den Boogaard, Gideon Caplan, John W Devlin, Michaela-Elena Friedrich, Willem A van Gool, James Hanison, Hans-Christian Hansen, Sharon K Inouye, Barbara Kamholz, Katarzyna Kotfis, Matthew B Maas, Alasdair M J MacLullich, Edward R Marcantonio, Alessandro Morandi, Barbara C van Munster, Ursula Müller-Werdan, Alessandra Negro, Karin J Neufeld, Peter Nydahl, Esther S Oh, Pratik Pandharipande, Finn M Radtke, Sylvie De Raedt, Lisa J Rosenthal, Robert Sanders, Claudia D Spies, Emma R L C Vardy, Eelco F Wijdicks, Arjen J C Slooter
Delirium (Bielefeld, Germany), 2024, vol. 2024
Cohort profile of PLUTO Nikki de Mul, Diede Verlaan, Jelle P Ruurda, Wilhelmina M U van Grevenstein, Jeroen Hagendoorn, Gert-Jan de Borst, Menno R Vriens, Remco de Bree, Ronald P Zweemer, Charles Vogely, Jelle L G Haitsma Mulier, Lisette M Vernooij, Johannes B Reitsma, Marcel R de Zoete, Janetta Top, Jan A J Kluijtmans, Imo E Hoefer, Peter Noordzij, Thijs Rettig, Marije Marsman, Anne Marie G A de Smet, Lennie Derde, Judith van Waes, Mienke Rijsdijk, Willem Jan M Schellekens, Marc J M Bonten, Arjen J C Slooter, Olaf L Cremer
BMJ Open, 2023, vol. 13

External positions

Arjen Slooter is unpaid advisor for Prolira, a start-up company that develops an EEG-based delirium monitor. Any (future) profits from EEG-based delirium monitoring will be used for future scientific research only.

Visiting Professor, Vrije Universiteit Brussel