Profile photo Arjen Slooter

Arjen Slooter

Full Professor

Strategic program(s):

Biography

Arjen Slooter studied Medicine at the Vrije Universiteit, Amsterdam and worked subsequently as a resident in Neurology in Sint Lucas Hospital, Amsterdam (1994). He was research fellow in Neuro-Epidemiology at the G.H. Sergievsky Center, Columbia University, New York (1996), and received a PhD in Epidemiology from Erasmus University, Rotterdam (1998), on a thesis on dementia. During his residency in Neurology at UMC Utrecht (1999-2004), he became enthusiastic for Neurocritical Care. After a fellowship in Intensive Care Medicine (AMC Amsterdam, 2004-2006), he rejoined UMC Utrecht where he worked until 2022 as a consultant neurologist-intensivist at the Department of Intensive Care Medicine. In 2016, he was appointed as Professor of Intensive Care Neuropsychiatry at Utrecht University. Dr Slooter was chair of the delirium section of the (American) Society of Critical Care Medicine (SCCM) guidelines on pain, agitation/sedation, delirium, immobility, and sleep disruption, as well as initiator and chair of an international consortium to update nomenclature on delirium and acute encephalopathy. From 2018 to 2023 he was President of the European Delirium Association. In 2022, he made a career shift to psychiatry.

The research focus of Arjen Slooter is on delirium and on neuropsychiatric outcome after anesthesia/surgery or critical illness. Using various methods and approaches (epidemiology, EEG, MRI), he has investigated all aspects of delirium, including its phenomenology and brain network characteristics, detection and monitoring, risk factors, prognosis, prevention and treatment. Research on neuropsychiatric outcomes includes ICU-related risk factor analyses on cognitive decline, mental illness and chronic pain after critical illness and treatment in the ICU. Arjen lives with his wife Barbara, daughter Pien and son Bas in beautiful Utrecht.

Most recent key publications

1. Van den Boogaard M, Slooter AJC, Brüggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P; REDUCE Study Investigators. Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA 2018;319:680-90. Impact Factor (IF) 157. 

2. Numan T, van den Boogaard M, Kamper AM, Rood PJT, Peelen LM, Slooter AJC; Dutch Delirium Detection Study Group. Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study. Br J Anaesth 2019;122:60-8. IF 9.9.

3. Slooter AJC, Otte WM, Devlin JW, Arora RC, Bleck TP, Claassen J, Duprey MS, Ely EW, Kaplan PW, Latronico N, Morandi A, Neufeld KJ, Sharshar T, MacLullich AMJ, Stevens RD. Updated nomenclature of delirium and acute encephalopathy: statement of ten societies. Intensive Care Med 2020;46:1020-2. IF 42.

4. Wilson JE, Mart M, Cunningham C, Shehabi Y, Girard T, MacLullich A, Slooter AJC, EW Ely. Delirium. Nature Rev Dis Primers 2020;6:90. IF 52. 

5. Duprey MS, Dijkstra-Kersten SMA, Zaal IJ, Briesacher BA, Saczynski JS, Griffith JL, Devlin JW, Slooter AJC. Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain. Am J Respir Crit Care Med 2021;204:566-72. IF 30.5. 

Strategic program(s):

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Research groups

Brain at risk

Research aim

The general aim of our research group is to decrease the burden of delirium during hospital admission and to improve outcome thereafter. Delirium is a frequent and serious complication that increases the risk of dementia.

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Recent publications

Single-channel qEEG characteristics distinguish delirium from no delirium, but not postoperative from non-postoperative delirium D Y Lodema, F L Ditzel, S C A Hut, E van Dellen, W M Otte, A J C Slooter
Clinical Neurophysiology, 2024, vol. 161, p.93-100
The risk of delirium after sedation with propofol or midazolam in intensive care unit patients Thomas G van Gelder, Irene J van Diem-Zaal, Sandra M A Dijkstra-Kersten, Nikki de Mul, Arief Lalmohamed, Arjen J C Slooter
British Journal of Clinical Pharmacology, 2024, vol. 90, p.1471-1479
Changes in quality of life 1 year after intensive care Lucy L Porter, Koen S Simons, Stijn Corsten, Brigitte Westerhof, Thijs C D Rettig, Esther Ewalds, Inge Janssen, Crétien Jacobs, Susanne van Santen, Arjen J C Slooter, Margaretha C E van der Woude, Johannes G van der Hoeven, Marieke Zegers, Mark van den Boogaard
Critical care (London, England), 2024, vol. 28
A Biopsychosocial Approach to Persistent Post-COVID-19 Fatigue and Cognitive Complaints Simona Klinkhammer, Annelien A. Duits, Kay Deckers, Janneke Horn, Arjen J.C. Slooter, Esmée Verwijk, Caroline M. van Heugten, Johanna M.A. Visser-Meily, Marcel J.H. Aries, Bas C.T. van Bussel, Jacobus F.A. Jansen, Marcus L.F. Janssen, Susanne van Santen, Fabienne J.H. Magdelijns, Rein Posthuma, David E.J. Linden, Margaretha C.E. van der Woude, Tom Dormans, Amy Otten, Alida A. Postma, Attila Karakus, Inez Bronsveld, Karin A.H. Kaasjager, Niek Galenkamp, Gert J. Geurtsen, Matthijs C. Brouwer, Kees Brinkman, Wytske A. Kylstra, Dook W. Koch, Martijn Beudel,
Archives of Physical Medicine and Rehabilitation, 2024, vol. 105, p.826-834
Whole blood thiamine, intravenous thiamine supplementation and delirium occurrence in the intensive care unit Muhammad A Mumin, Cathrine A McKenzie, Valerie J Page, Daniel Hadfield, Leanne M Aitken, Fraser Hanks, Emma Cunningham, Bronagh Blackwood, Edwin Van Dellen, Arjen J C Slooter, Michael P W Grocott, Daniel F McAuley, Peter E Spronk
International journal of clinical pharmacy, 2024, vol. 46, p.631-638
International Delirium Pathophysiology & Electrophysiology Network for Data sharing (iDEPEND) Robert D. Sanders, Leiv Watne, Shawniqua Williams Roberson, Eyal Y. Kimchi, Arjen J.C. Slooter, Colm Cunningham, Kirill V. Nourski, Ben J.A. Palanca, Richard Lennertz, Matthew I. Banks
BJA open, 2024, vol. 11

External positions

No external positions -