Profile photo Zsolt Sebestyen

Zsolt Sebestyen

Associate Professor

Biography

Obtained his PhD in Hungary at University of Debrecen, where he became fascinated by biophysical techniques that he learned to use to study molecular interactions in living cells. He was further trained in the Babraham Institute In Cambridge (UK) and later at the ErasmusMC in Rotterdam (NL) where he as postdoctoral fellow has studied the molecular needs of genetic engineering of T cells for the immunotherapy of cancer. He continued his career at the UMCU in Utrecht, where he was appointed in 2014 as staff member of Section Applied within the Laboratory of Translational Immunology. He is currently focusing on the developement of novel gamma delta T cell-based immunotherapies and the better understanding of innate T cell and tumour cell interactions.  Reserach interest:  Tumour recognition of innate immune cells, Immune receptors , Genetic engineering.

Research groups

Tumor Immunology

Research aim

Our research aims to revolutionise cancer treatment by advancing innovative immunotherapies, ensuring safer, more effective therapies, and improving patient outcomes, ultimately transforming lives through cutting-edge translational cancer research.

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Recent publications

Author Correction Thomas Kimman, Marta Cuenca, Ralph G Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D Meringa, Wendy Boschloo, Douwe M T Bosma, Sanne Kroos, Vania Lo Presti, Joost P G Sluijter, Stefan Nierkens, Niels Bovenschen, Jürgen Kuball, Alain van Mil, Monique C Minnema, Zsolt Sebestyén, Victor Peperzak
Nature Communications, 2026, vol. 17
Commentary on "Comparative efficacy and safety of PSCA CAR-engineered Vδ1 γδ T cells for immunotherapy of pancreatic cancer" Dorine A de Bont, Trudy Straetemans, Zsolt Sebestyén, Jurgen Kuball
Journal for immunotherapy of cancer, 2026, vol. 14
De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function Nils Bessler, Amber K.L. Wezenaar, Hendrikus C.R. Ariese, Celina Honhoff, Noëlle Dommann, Ellen J. Wehrens, Cristian Ruiz Moreno, Thijs J.M. van den Broek, Raphaël V.U. Collot, Daan J. Kloosterman, Farid Keramati, Mieke Roosen, Sam de Blank, Esmée van Vliet, Mario Barrera Román, Lucrezia C.D.E. Gatti, Ali Ertürk, Jürgen Kuball, Zsolt Sebestyén, Marcel Kool, Sara Patrizi, Evelina Miele, Annette Künkele, Mariëtte E.G. Kranendonk, Annelisa M. Cornel, Stefan Nierkens, Christian Mayer, Hendrik G. Stunnenberg, Anna Alemany, Maria Alieva, Anne C. Rios
Nature Cancer, 2026, vol. 7, p.316–333
Current capacity and gaps in viral vector manufacturing Ganesh Ramesh, Zsolt Sebestyen, Anil Kumar Deshantri, Simone Punt, Emma Martinez Sanchez, Jesus Fernandez-Sojo, Sergi Querol, Michael Hudecek, Carmen Sanges, Ruud Das, Aiko Ballardini, Cristina Eguizabal, Dirk Geerts, Ardeshir Ghavamzadeh, Virginia Escamilla Gómez, Manel Juan, Thomas Stauffer Larsen, Petr Lesný, Daniel Lysák, Mirko Müller, Unai Perpiñá, Sofieke de Wilde, Florent Malard, Jorinde Hoogenboom, Jarl Mooyaart, Annalisa Ruggeri, Trudy Straetemans, Jurgen Kuball
Bone Marrow Transplantation, 2025, vol. 61, p.245-248
Autologous profiling reveals inter-patient heterogeneity in Vδ2 +γδTIL responses to glioblastoma driven by extracellular matrix-BTN3A axis. Mara J T Nicolasen, Lucrezia Cde Gatti, Laia Gasull-Celades, Peter Brazda, Marta Botas, Daniel Zawal, Esmee J van Vliet, Astrid Cleven, Zsolt Sebestyén, Pierre A Robe, Dennis X Beringer, Jurgen Kuball
Journal for immunotherapy of cancer, 2025, vol. 13
A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma Michael Rade, David Fandrei, Markus Kreuz, Sabine Seiffert, Anja Grahnert, Maik Friedrich, Thomas Wiemers, Patrick Born, Luise Fischer, Heike Weidner, Lorenz C. Hofbauer, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Jonathan Scolnick, Mirco Friedrich, Farid Keramati, Peter Brazda, Zsolt Sebestyen, Jürgen Kuball, Miriam Alb, Lukas Scheller, Michael Hudecek, Hermann Einsele, Klaus H. Metzeler, Marco Herling, Carmen Diana Herling, Madlen Jentzsch, Georg Nikolaus Franke, Andreas Boldt, Ulrike Köhl, Uwe Platzbecker, Vladan Vucinic, Kristin Reiche, Maximilian Merz
Cancer Cell, 2025, vol. 44, p.586-603.e9