Biography
Sacha Spelier is an Assistant Professor at UMC Utrecht and leads the cystic fibrosis patient-derived intestinal organoid (CF-PDIO) research line. She obtained her MSc in Cancer, Stem Cells & Developmental Biology at Utrecht University and completed her PhD on nonsense mutation therapeutics and functional disease modelling in cystic fibrosis. Her research focuses on understanding and overcoming nonsense mutations using patient-derived organoid models and quantitative functional assays. In parallel, she studies CF-associated complications, including ageing and colorectal cancer, to better understand the long-term consequences of CFTR dysfunction. Her work bridges fundamental biology, translational research and precision medicine, with the goal of developing better therapies for people with cystic fibrosis and other genetic diseases.
