Sabine Linn

Full Professor

Strategic program(s):

Contact

slinn2@umcutrecht.nl

Pure profile

Research groups

Translational breast cancer research group

Research aim

We aim to optimize early diagnosis and treatment of breast cancer, especially rare breast cancers like pregnancy associated, male & lobular breast cancer. We refine tissue diagnostics with molecular techniques/AI, and apply nipple fluid/blood tests.

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Recent publications

All publications

Targeting homologous recombination deficiency with intensified chemotherapy versus standard chemotherapy followed by olaparib in stage III breast cancer (SUBITO) Rianne L Seefat, Sonja B Vliek, Vincent M T de Jong, Sara Balduzzi, Ingrid A Mandjes, Valesca P Retèl, Inge Eekhout, Marjolein Delfos, Margaret Schot, Marjo J Holtkamp, Mandy M van Rosmalen, Brenda Leeneman, Hedwig Blommestein, Alwin D R Huitema, Efraim H Rosenberg, Petra M Nederlof, Terry W S Chan, Anna van Rhenen, Marielle J Wondergem, Nicolaas P M Schaap, Tjeerd J F Snijders, Marjolein W M Van der Poel, Wouter J Plattel, Erik van Werkhoven, Harm van Tinteren, Marjolein L Smidt, Jelle Wesseling, Jos Jonkers, Sven Rottenberg, Marie-Jeanne T F D Vrancken Peeters, Carlijn Voermans, John H Maduro, Judith R Kroep, Carolien P Schroder, Evelien J M Kuip, Anthony Gonçalves, Janine Nuver, A N Machteld Wymenga, Rhodé M Bijlsma, Elsken van der Wall, Inge R H M Konings, Vivianne C G Tjan-Heijnen, Mojca Jongen-Lavrencic, Agnes Jager, Sabine C Linn
The Lancet Oncology, 2026, vol. 27, p.795-807

Central nervous system and leptomeningeal metastases in patients with HER2-positive breast cancer Aldo Caltavituro, Roberto Buonaiuto, Alessandra Longobardi, Paola Trasacco, Claudia Martinelli, Giuseppe Di Grazia, Roberto Pacelli, Grazia Arpino, Carmine De Angelis, Roberta Caputo, Michelino De Laurentiis, Elena Laakmann, Leonor Vasconcelos de Matos, Mário Fontes-Sousa, Mette van Ramshorst, Volkmar Mueller, Elisa Agostinetto, Sabine Linn, Michelangelo De Angelis, Francesco Schettini, Mario Giuliano
Cancer treatment reviews, 2026, vol. 147

Coverage with evidence development programs Joost G.E. Verbeek, Rianne L. Seefat, Erica A. Wilthagen, Agnes Jager, Sabine C. Linn, Valesca P. Retèl, Wim H. van Harten
Health Policy, 2026, vol. 171

Towards patient-centered research in pregnancy-associated breast cancer Carsten F.J. Bakhuis, Anna S. Koning, Britt B.M. Suelmann, Inge O. Baas, Janna W. Nijkamp, Kirsten Coutinho-Steentjes, Pleun A. Gilsing-Doreleijers, Manuela Guerra, Aaltje G.H. Hoppentocht, Elsemieke Kaashoek-de Jong, Nicol Nijholt, Roselien van der Wielen, Jan Ewout Ruiter, Sabine C. Linn, Stefan Preković, Paul J. Van Diest, Elsken van der Wall, Carmen van Dooijeweert
Breast, 2026, vol. 88

PI3K Inhibition in Combination with Tamoxifen in Patients with Metastatic HR+/HER2− Breast Cancer Rosie A.B. Voorthuis, Mafalda Oliveira, Annelot G.J. van Rossum, Leonora W. de Boo, Ingrid A.M. Mandjes, Cristina Saura, Susana Muñoz, Dario López García, Mariette Schrier, Karolina Sikorska, Marta Lopez-Yurda, Margaret Schot, Tatjana Westphal, Catharina M. Korse, Shubha Anand, Rene Bernards, William M. Gallaher, Karin Beelen, Carlos Caldas, Javier Cortes, Sabine C. Linn, Richard D. Baird
Clinical Cancer Research, 2026, vol. 32, p.1983-1994

Pathway activity profiling can predict neoadjuvant endocrine therapy response in HR+ HER2- postmenopausal early stage breast cancer N de Gruil, A F de Groot, Y Wesseling-Rozendaal, D Keizer, C S Koekenbier, S Vermeer, D Cohen, J B Heijns, C M P W Mandigers, A J van de Wouw, M Cloos-van Balen, J A Ropela, H M Oosterkamp, M L van Bekkum, D Houtsma, E den Biezen, G J Liefers, S C Linn, J R Kroep
Breast Cancer Research, 2026, vol. 28