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Profile photo Roelie Wösten-van Asperen

Roelie Wösten-van Asperen

Associate Professor

Strategic program(s):

Biography

Roelie Wösten-van Asperen  is a pediatric-intensivist at the PICU of the Wilhelmina Children’s Hospital in Utrecht. She started her fellowship in pediatric intensive care in 2002. After finalization of her fellowship, she has been a consultant pediatric intensivist in the Emma Children’s Hospital/Academic Medical Center, Amsterdam. In 2011, she defended her thesis ‘The role of the renin-angiotensin system in acute lung injury’ at the University of Amsterdam.

After almost 15 years (in January 2016), she moved from the PICU of the Emma Children’s Hospital to the PICU of the Wilhelmina Children’s Hospital in Utrecht. Together with Prof. Marry van den Heuvel of the Princess Máxima Center for Pediatric Oncology, she started a research group on pediatric cancer patients at the PICU.

She is currently chair of the PICU Oncology Kids in Europe Research group (POKER), a research consortium comprising of 21 PICU’s which are adhered to large pediatric oncological centers in 11 different countries (Austria, Belgium, Denmark, Germany, France, Italy, Poland, Spain, Switzerland, the Netherlands, and the UK). Our mission is to improve our understanding and our ability to appropriately treat these patients, thereby improving outcomes of children with cancer who are admitted to the PICU. 

 

Education/training

1988-1993 Medical Biology, Groningen University, Groningen, The Netherlands Degree: MSc (cum laude)

1991-1995 Medicine, Groningen University, Groningen, The Netherlands. Degree: MSc (cum laude)

1995-1997 Medical Degree Groningen University, Groningen, The Netherlands. Degree: MD (cum laude)

1997-2002 Training in pediatrics, University of Leiden (1997-1999) and University of Groningen (2000-2002), The Netherlands

2002-2006 Fellowship pediatric intensive care medicine, Emma Children’s Hospital/Academic Medical Center, Amsterdam, The Netherlands

2005-2011 PhD ‘The role of the renin angiotensin system in acute lung injury’, University of Amsterdam, Amsterdam, The Netherlands

 

Researchline

Pediatric cancer patients at the PICU: identifying prognostic factors influencing PICU admission and outcome of pediatric cancer patients.

 

Recent publications

β-Lactam dosing in critically ill children Stef Schouwenburg, Tim Preijers, Roelie M Wösten-Van Asperen, Enno D Wildschut, Nelianne J Verkaik, Alan Abdulla, Matthijs de Hoog, Birgit C P Koch
The Journal of antimicrobial chemotherapy, 2025, vol. 81
Low Target Attainment of Intravenous Cefuroxime in Critically Ill Term Neonates and Children Stef Schouwenburg, Tim Preijers, Roelie M.Wösten van Asperen, Stan J.F. Hartman, Saskia N. de Wildt, Matthijs de Hoog, Birgit C.P. Koch, Alan Abdulla, Enno D. Wildschut
Clinical Pharmacokinetics, 2025, vol. 65, p.97-108
Developing organ dysfunction diagnostic criteria for children with cancer and post-hematopoietic cell transplantation Michael Bashir, Sayeda Islam, Jordan Wrigley, Anita Arias, Roelie M. Wösten-van Asperen, Kimberly K. Kertis, Melissa M. Hudson, Courtney M. Rowan, Aimee C. Talleur, Joshua Wolf, Benjamin Oelkers, Melissa R. Hines, Asya Agulnik
Frontiers in oncology, 2025, vol. 15
Nephrotoxicity and kidney outcomes in pediatric oncology patients Paulien A M A Raymakers-Janssen, Nils Leitzinger, Gerrit van den Berg, Joppe Nijman, Mieke I Triest, Ellen Kilsdonk, Inge A van Kessel, Lidwien M Hanff, Martine van Grotel, Marc H W A Wijnen, Roelie M Wösten-van Asperen, Marc R Lilien, Marry M van den Heuvel-Eibrink, Marta Fiocco
Nephrology Dialysis Transplantation, 2025, vol. 41, p.345-352
The Full Burden of RSV-related Pediatric Intensive Care Unit Admissions During Infancy Emily W.E.M. Phijffer, Joanne G. Wildenbeest, Carole N.M. Brouwer, Matthijs De Hoog, Martin C.J. Kneyber, Sofie Maebe, Anneliese Nusmeier, Maaike A. Riedijk, Roelie M. Wösten-Van Asperen, Louis J. Bont, Job B.M. Van Woensel
Pediatric Infectious Disease Journal, 2025, vol. 44, p.517-521

Fellowships & Awards

Funding as Co-PI:

2012 Academic Medical Center Graduate School Scholarship: Impact of age on the pulmonary renin-angiotensin system in acute respiratory distress syndrome (Euro 205K)

2017 Research grant supported by KiKa: Identifying the critically ill pediatric cancer patient. (Euro 590K)