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Profile photo Roelie Wösten-van Asperen

Roelie Wösten-van Asperen

Associate Professor

Strategic program(s):


Roelie Wösten-van Asperen  is a pediatric-intensivist at the PICU of the Wilhelmina Children’s Hospital in Utrecht. She started her fellowship in pediatric intensive care in 2002. After finalization of her fellowship, she has been a consultant pediatric intensivist in the Emma Children’s Hospital/Academic Medical Center, Amsterdam. In 2011, she defended her thesis ‘The role of the renin-angiotensin system in acute lung injury’ at the University of Amsterdam.

After almost 15 years (in January 2016), she moved from the PICU of the Emma Children’s Hospital to the PICU of the Wilhelmina Children’s Hospital in Utrecht. Together with Prof. Marry van den Heuvel of the Princess Máxima Center for Pediatric Oncology, she started a research group on pediatric cancer patients at the PICU.

She is currently chair of the PICU Oncology Kids in Europe Research group (POKER), a research consortium comprising of 21 PICU’s which are adhered to large pediatric oncological centers in 11 different countries (Austria, Belgium, Denmark, Germany, France, Italy, Poland, Spain, Switzerland, the Netherlands, and the UK). Our mission is to improve our understanding and our ability to appropriately treat these patients, thereby improving outcomes of children with cancer who are admitted to the PICU. 



1988-1993 Medical Biology, Groningen University, Groningen, The Netherlands Degree: MSc (cum laude)

1991-1995 Medicine, Groningen University, Groningen, The Netherlands. Degree: MSc (cum laude)

1995-1997 Medical Degree Groningen University, Groningen, The Netherlands. Degree: MD (cum laude)

1997-2002 Training in pediatrics, University of Leiden (1997-1999) and University of Groningen (2000-2002), The Netherlands

2002-2006 Fellowship pediatric intensive care medicine, Emma Children’s Hospital/Academic Medical Center, Amsterdam, The Netherlands

2005-2011 PhD ‘The role of the renin angiotensin system in acute lung injury’, University of Amsterdam, Amsterdam, The Netherlands



Pediatric cancer patients at the PICU: identifying prognostic factors influencing PICU admission and outcome of pediatric cancer patients.


Recent publications

Healthcare costs related to respiratory syncytial virus in paediatric intensive care units in the Netherlands Emily W.E.M. Phijffer, Joanne G. Wildenbeest, Carole N.M. Brouwer, Matthijs de Hoog, Martin C.J. Kneyber, Sofie Maebe, Anneliese Nusmeier, Maaike A. Riedijk, Roelie M. Wösten-van Asperen, Job B.M. van Woensel, Louis J. Bont, Geert J.W. Frederix
The Lancet Regional Health - Europe, 2024, vol. 43
Paediatric cancer patients with severe sepsis or septic shock at the PICU with positive microbiological results do worse than those with negative results: a retrospective cohort study Lisette Veling, Fernanne van Wolffelaar, J van der Bruggen, Michiel van der Flier, Wim Tissing, RM Wösten-van Asperen
Intensive Care Medicine Paediatric and Neonatal, 2024, vol. 2
Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study Roelie M. Wösten-van Asperen, Hannah M. la Roi-Teeuw, Rombout BE van Amstel, Lieuwe DJ Bos, Wim JE Tissing, Iolanda Jordan, Christian Dohna-Schwake, Gabriella Bottari, John Pappachan, Roman Crazzolara, Rosanna I. Comoretto, Agniezka Mizia-Malarz, Andrea Moscatelli, María Sánchez-Martín, Jef Willems, Colin M. Rogerson, Tellen D. Bennett, Yuan Luo, Mihir R. Atreya, E. Vincent S. Faustino, Alon Geva, Scott L. Weiss, Luregn J. Schlapbach, L. Nelson Sanchez-Pinto, Marina Caballero, Adriana Margarit, Roi Campos, Paula Möller, Carmela Serpe, Angela Amigoni, Maria Damps, Alessia Montaguti, Giacomo Tardini, Juliane Bubeck-Wardenburg, Reid Farris Farris, Mark Hall, Grace Chong, Sareen Shah, Robinder Khemani, Emily Stroup, ,
EClinicalMedicine, 2023, vol. 65
Validation of a modified bedside Pediatric Early Warning System score for detection of clinical deterioration in hospitalized pediatric oncology patients Marijn Soeteman, Teus H. Kappen, Martine van Engelen, Maartje Marcelis, Ellen Kilsdonk, Marry M. van den Heuvel-Eibrink, Edward E.S. Nieuwenhuis, Wim J.E. Tissing, Marta Fiocco, Roelie M.Wösten van Asperen
Pediatric Blood and Cancer, 2023, vol. 70
Prognostic factors for multi-organ dysfunction in pediatric oncology patients admitted to the pediatric intensive care unit Marijn Soeteman, Marta F Fiocco, Joppe Nijman, Casper W Bollen, Maartje M Marcelis, Ellen Kilsdonk, Edward E S Nieuwenhuis, Teus H Kappen, Wim J E Tissing, Roelie M Wösten-van Asperen
Frontiers in oncology, 2023, vol. 13
Lung function decline preceding chronic respiratory failure in spinal muscular atrophy Esther S Veldhoen, Camiel A Wijngaarde, Ruben P A van Eijk, Fay-Lynn Asselman, Negina Seddiqi, Louise A M Otto, Marloes Stam, Inge Cuppen, Renske I Wadman, Roelie M Wösten van Asperen, Erik H J Hulzebos, Laura P Verweij van den Oudenrijn, Bart Bartels, Jasmijn Boezer, M Gaytant, Cornelis K van der Ent, W Ludo van der Pol
Orphanet Journal of Rare Diseases, 2023, vol. 18