Robert Jan Lebbink

Associate Professor

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Research aim

To uncover new mechanisms of virus-host interactions and develop innovative antiviral strategies using genome engineering technologies.

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The essential role of heparan sulfate in the entry of PDCoV and other porcine coronaviruses Ningning Ma, Mengjia Zhang, Ahmed H Ghonaim, Pei Zhou, Chunyan Wang, Jiaru Zhou, Guanghao Guo, Robert Jan Lebbink, Berend Jan Bosch, Hongmei Zhu, Wentao Li, Qigai He
Virulence, 2026, vol. 17

Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections Guanghao Guo, Mengjia Zhang, Zhuojia Xu, Peng Xi, Hongmei Zhu, Anouk Evers, Robert Jan Lebbink, Yifei Lang, Qigai He, Yao-Wei Huang, Tiehai Li, Berend Jan Bosch, Wentao Li
mBio, 2025, vol. 16

Multi-proteomic profiling of the varicella-zoster virus-host interface reveals host susceptibilities to severe infection Virginie Girault, Alexey Stukalov, Madalina Elena Carter-Timofte, Jonny Hertzog, Melissa Verin, Katharina Austen, Darya A Haas, Lila Oubraham, Antonio Piras, Susanne Maidl, Rupert Öllinger, Roland Rad, Ulrike Protzer, Benedikt B Kaufer, Robert J Lebbink, Jan Rehwinkel, Trine H Mogensen, Andreas Pichlmair
Nature Microbiology, 2025, vol. 10, p.2048-2072

Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening Xuesheng Wu, Rutger D Luteijn, Estefanía Lozano-Andrés, Katherine Marougka, Wentao Li, Yoshiki Narimatsu, Frank J M van Kuppeveld, Berend Jan Bosch, Robert Jan Lebbink, Erik de Vries, Cornelis A M de Haan
Emerging microbes & infections, 2025, vol. 14

Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection Ningning Ma, Mengjia Zhang, Jiaru Zhou, Changsheng Jiang, Ahmed H. Ghonaim, Yumei Sun, Pei Zhou, Guanghao Guo, Anouk Evers, Hongmei Zhu, Qigai He, Robert Jan Lebbink, Berend Jan Bosch, Wentao Li
Emerging microbes & infections, 2024, vol. 13

CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation Shuxuan Zheng, Georges M.G.M. Verjans, Anouk Evers, Ellen van den Wittenboer, Jeroen H.T. Tjhie, Robert Snoeck, Emmanuel J.H.J. Wiertz, Graciela Andrei, Jeroen J.A. van Kampen, Robert Jan Lebbink
Antiviral Research, 2024, vol. 228