Profile photo Raymond Schiffelers

Raymond Schiffelers

Full Professor

Strategic program(s):

Biography

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.

 

Research groups

Nanomedicine lab

Research aim

We develop synthetic and biological nanomedicine for targeted drug delivery

Go to group

Recent publications

Efficiency and immunogenicity of lipid nanoparticle-mediated cardiac mRNA delivery are lipid composition-dependent Maria C.I. Labonia, Pol Escudé Martinez de Castilla, Petra H. van der Kraak, Maike A.D. Brans, Qiangbing Yang, Zhiyong Lei, Saskia C.A. de Jager, Willemijn S. de Voogt, Raymond M. Schiffelers, Joost P.G. Sluijter, Pieter Vader
Molecular Therapy Nucleic Acids, 2026, vol. 37
Photoporation enables non-viral delivery of prime editing RNP complexes into human iPSC-derived cardiomyocytes for cardiac genome correction Bing Yao, Geng Yang, Qian Wang, Mark A. Daniels, Inge Dokter, Peng Shang, Alain van Mil, Pieter A. Doevendans, Manuel A.F.V. Gonçalves, Francesca Stillitano, Joost P.G. Sluijter, Raymond Schiffelers, Zhiyong Lei
Biomedicine and Pharmacotherapy, 2026, vol. 198
Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction Caren van Kammen, Myrthe Brink, Magdalena Minnion, Martin Feelisch, Raymond Schiffelers, Titia Lely, Fieke Terstappen
Scientific Reports, 2026, vol. 16
Longitudinal 3D-DCE MRI Assessment of Placental Perfusion Under Reduced Uterine Perfusion Pressure in Pregnant Rats Fatimah M M. Al Darwish, Caren M van Kammen, Fieke Terstappen, Lindy K Alles, Raymond M Schiffelers, A.  Titia Lely, Gustav J Strijkers, Bram F Coolen
NMR in Biomedicine, 2026, vol. 39
Toward In Vivo CAR T Cell Therapy Ludovica Sciuto, Sander A A Kooijmans, Raymond M Schiffelers
Nano letters, 2026, vol. 26, p.2337-2347
Magnetic Lipid Nanoparticles for Targeted mRNA Delivery and Enhanced Organ-Specific Expression Xin Jin, Qiangbin Yang, Liqiang Yang, Geng Yang, Juntao Fang, Cornelis Seinen, Mark Daniëls, Christian Snijders Blok, Arjan Barendrecht, Arnold Koekman, Mies J van Steenbergen, Enrico Mastrobattista, Joost P G Sluijter, Raymond M Schiffelers, Jiong-Wei Wang, Zhiyong Lei
ACS Applied Materials and Interfaces, 2026, vol. 18, p.12406–12422

Fellowships & Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

External positions

Scientist - Projectadvies - Hospital del Mar Research Inistitute Barcelona

Binnen Nanocell Therapeutics heb ik de functie van VP Preclinical R&D - supervisie onderzoekers op het gebied van preklinische R&D van nanomedicines - Nanocell Therapeutics

Scientific Advisory Board - bedrijf ontwikkelt producten op mijn vakgebied - SentryX bv

associate editor - publicatie op mijn vakgebied - Drug Delivery & Translational Research

Chief Scientific Officer - Wetenschappelijke ontwikkelingen signaleren en onderzoeksstrategie bepalen - Excytex bv