Profile photo Paul van Diest

Paul van Diest

Full Professor

Strategic program(s):

Biography

Paul J van Diest has been a dedicated cancer researcher since the start of his career, obtaining numerous grants a.o. from the NIH and the Dutch Cancer Society. He studied Medicine, did his PhD and pathology residency at the VU University medical center (VUMC) in Amsterdam. After obtaining his Board certification in Pathology in 1996, he became Consultant Pathologist at the Department of Pathology of the VUMC. In 1999 he was appointed Associate Professor and in 2001 to full Professor. In 2003 he moved to Utrecht to become Head of the Department of Pathology at the University Medical Center Utrecht (UMCU) where he is currently still working. He is Adjunct Professor of Oncology at the Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA. He serves on the editorial board of >20 international journals. He has been active in the board as secretary and president of several international societies. He has published >900 papers in peer reviewed journals, personally supervised 90 PhD theses, and has an H-index of 99. The main theme of his research is finding ways for prevention, optimized diagnosis and cure of breast cancer, both the male and female forms. He is also active in the field of implementing digital pathology and AI.

Strategic program(s):

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Research groups

Translational breast cancer research group

Research aim

We aim to optimize early diagnosis and treatment of breast cancer, especially rare breast cancers like pregnancy associated, male & lobular breast cancer. We refine tissue diagnostics with molecular techniques/AI, and apply nipple fluid/blood tests.
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AI in pathology

Research aim

To develop, validate, and implement AI in digital pathology practice
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Recent publications

Predicting response to neoadjuvant chemotherapy with liquid biopsies and multiparametric MRI in patients with breast cancer L. M. Janssen, M. H.A. Janse, B. B.L. Penning de Vries, B. H.M. van der Velden, E. J.M. Wolters-van der Ben, S. M. van den Bosch, A. Sartori, C. Jovelet, M. J. Agterof, D. Ten Bokkel Huinink, E. W. Bouman-Wammes, P. J. van Diest, E. van der Wall, S. G. Elias, K. G.A. Gilhuijs
npj Breast Cancer, 2024, vol. 10
Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status Yuwei Wang, Gwen M H E Dackus, Efraim H Rosenberg, Sten Cornelissen, Leonora W de Boo, Annegien Broeks, Wim Brugman, Terry W S Chan, Paul J van Diest, Michael Hauptmann, Natalie D Ter Hoeve, Olga I Isaeva, Vincent M T de Jong, Katarzyna Jóźwiak, Roelof J C Kluin, Marleen Kok, Esther Koop, Petra M Nederlof, Mark Opdam, Philip C Schouten, Sabine Siesling, Charlaine van Steenis, Adri C Voogd, Willem Vreuls, Roberto F Salgado, Sabine C Linn, Marjanka K Schmidt
BMC Medicine, 2024, vol. 22, p.1-14
The Diagnostic Value of microRNA Expression Analysis in Detecting Intraductal Papillomas in Patients with Pathological Nipple Discharge Seher Makineli, Menno R. Vriens, Arjen J. Witkamp, Paul J. van Diest, Cathy B. Moelans
International Journal of Molecular Sciences, 2024, vol. 25
Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer L W de Boo, K Jóźwiak, N D Ter Hoeve, P J van Diest, M Opdam, Y Wang, M K Schmidt, V de Jong, S Kleiterp, S Cornelissen, D Baars, R H T Koornstra, E D Kerver, T van Dalen, A D Bins, A Beeker, S M van den Heiligenberg, P C de Jong, S D Bakker, R C Rietbroek, I R Konings, R Blankenburgh, R M Bijlsma, A L T Imholz, N Stathonikos, W Vreuls, J Sanders, E H Rosenberg, E A Koop, Z Varga, C H M van Deurzen, A L Mooyaart, A Córdoba, E Groen, J Bart, S M Willems, V Zolota, J Wesseling, A Sapino, E Chmielik, A Ryska, A Broeks, A C Voogd, E van der Wall, S Siesling, R Salgado, G M H E Dackus, M Hauptmann, M Kok, S C Linn
ESMO open, 2024, vol. 9
Image-based multiplex immune profiling of cancer tissues Chowdhury Arif Jahangir, David B. Page, Glenn Broeckx, Claudia A. Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge S. Reis-Filho, Amy Ly, Paul W. Harms, Rajarsi R. Gupta, Michael Vieth, Akira I. Hida, Mohamed Kahila, Zuzana Kos, Paul J. van Diest, Sara Verbandt, Jeppe Thagaard, Reena Khiroya, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Sylvia Adams, Jonas S. Almeida, Isabel Alvarado-Cabrero, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Enrique R. Bellolio, Vydehi Bheemaraju, Kim R.M. Blenman, Luciana Botinelly Mendonça Fujimoto, Octavio Burgues, Alexandros Chardas, Maggie Chon U. Cheang, Francesco Ciompi, Lee A.D. Cooper, An Coosemans, Germán Corredor, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Sarah N. Dudgeon, Mahmoud Elghazawy, Claudio Fernandez-Martín, Susan Fineberg, Stephen B. Fox, Jennifer M. Giltnane, Sacha Gnjatic, Paula I. Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G. Hanna, Aparna Harbhajanka, Steven N. Hart, Johan Hartman, Stephen Hewitt, Hugo M. Horlings, Zaheed Husain, Sheeba Irshad, Emiel A.M. Janssen, Tatsuki R. Kataoka, Kosuke Kawaguchi, Andrey I. Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L. Kodach, Konstanty Korski, Guray Akturk, Ely Scott, Anikó Kovács, Anne Vibeke Lænkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K. Lennerz, Marvin Lerousseau, Xiaoxian Li, Anant Madabhushi, Sai K. Maley, Vidya Manur Narasimhamurthy, Douglas K. Marks, Elizabeth S. McDonald, Ravi Mehrotra, Stefan Michiels, Durga Kharidehal, Fayyaz ul Amir Afsar Minhas, Shachi Mittal, David A. Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D. Perera, Christopher J. Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T. Rau, Joana M. Ribeiro, David Rimm, Anne Vincent-Salomon, Joel Saltz, Shahin Sayed, Evangelos Hytopoulos, Sarah Mahon, Kalliopi P. Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A. Sughayer, Daniel Sur, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E. Aubrey Thompson, Trine Tramm, William T. Tran, Jeroen van der Laak, Gregory E. Verghese, Giuseppe Viale, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y. Wen, Wentao Yang, Yinyin Yuan, John Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Elisabeth Specht Stovgaard, Roberto Salgado, William M. Gallagher, Arman Rahman
Journal of Pathology, 2024, vol. 262, p.271-288
Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum Henriette S de Bruijn, Vida Mashayekhi, Tom J L Schreurs, Pieter B A A van Driel, Gustav J Strijkers, Paul J van Diest, Clemens W G M Lowik, Ann L B Seynhaeve, Timo L M Ten Hagen, Jeanine J Prompers, Paul M P van Bergen En Henegouwen, Dominic J Robinson, Sabrina Oliveira
Theranostics, 2024, vol. 14, p.1099-1100

External positions

Member of the Supervisory Board, Dutch Expert Center for Screening (LRCB)