Profile photo Gerard Pasterkamp

Gerard Pasterkamp

Full Professor

Strategic program(s):

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and quarter maker of the Circulatory Health Research Center, UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Recent publications

Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β Tim R Sakkers, Eloi Mili, Hanna Winter, Daniek Kapteijn, R Noah Perry, Nicolas Barbera, Kelsey Watts, Inês R Dias, Denitsa Meteva, Marian Wesseling, Barend M Mol, Gert J de Borst, Dominique P V de Kleijn, Sander W van der Laan, Mete Civelek, Stephen J White, Lars Maegdefessel, Manuel Mayr, Gerard Pasterkamp, Michal Mokry, Ernest Diez Benavente, Hester M den Ruijter
Circulation research, 2026, vol. 138
Disturbed flow induces reprogramming of endothelial cells to immune-like and foam cells under hypercholesterolaemia during atherogenesis Christian Park, Kyung In Baek, Ruei-Chun Hung, Leandro Choi, Kiyoung Jeong, Paul Kim, Andrew Keunho Jahng, Jung Hyun Kim, Yerin Kim, Mostafa Meselhe, Ashwin Kannan, Chien-Ling Chou, Dong Won Kang, Eun Ju Song, Jay Aaron Bowman-Kirigin, Michael David Clark, Sander W van der Laan, Gerard Pasterkamp, Nicolas Villa-Roel, Alyssa Panitch, Hanjoong Jo
Cardiovascular research, 2025, vol. 121, p.2679-2699
Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease Sophie C. de Ruiter, Marion van Vugt, Chris Finan, Diederick E. Grobbee, Dominique P.V. de Kleijn, Gerard Pasterkamp, Hester M. den Ruijter, Ernest Diez Benavente, Sanne A.E. Peters, A. Floriaan Schmidt
EBioMedicine, 2025, vol. 121
Carotid Plaques Show More Unstable Characteristics Between 2010 and 2021 After a Prior Decade of Stabilization Barend M. Mol, Tetiana Motsak, Joost K.R. Hoekstra, Gerard Pasterkamp, Gert J. de Borst, Dominique P.V. de Kleijn
Journal of the American Heart Association, 2025, vol. 14
High Levels of Plasma and Plaque IsoDGR-Modified Fibronectin are Associated with Rupture Prone Plaque Characteristics in Carotid Endarterectomy Patients Barend M. Mol, Tetiana Motsak, Joost K.R. Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofong Cam Ngan, Gerard Pasterkamp, Gert J. de Borst, Siu Kwan Sze, Dominique P.V. de Kleijn
European Journal of Vascular and Endovascular Surgery, 2025, vol. 70, p.287-294
Computational Modeling Predicts Benefits of Proefferocytic Therapy in Human Atherosclerosis Kai-Uwe Jarr, Kaylin C A Palm, Gerard Pasterkamp, Michal Mokry, Nicholas J Leeper
Circulation, 2025, vol. 152, p.208-211

External positions

reviewerspanel/commissie Health Holland ronde oktober 2024 - reviewen en met commissie belsuiten over honorering aanvragen - Health Holland

auteur - uitgeven van een boek, maar aantal uren is niet (meer) van toepassing. werk is al gedaan - persoonlijk, geen werkgever

Voorzitter Wetenschappelijke Adviesraad - Voorzitten vergaderingen - Reuma Nederland