Profile photo Monique Nijhuis

Monique Nijhuis

Associate Professor

Strategic program(s):

Biography

Monique Nijhuis obtained her PhD in 1999 at the University of Utrecht on the investigation of the impact of antiretoviral resistance on HIV fitness. Following postdoctoral research training in the US she initiated a research line at the interface between fundamental and clinical research and became an honourable Profssor of the University of the Witwatersrand in Johannesburg and an Associate Professor of Virology at the University Medical Center in Utrecht, the Netherlands. Her research interest are centred on (1) HIV reservoirs and eradication and (2) HIV drug resistance and evolution. She is heading the international multidisciplinary Spiral consortium investigating HIV cure strategies with a specific focus on sub-Saharan Africa, is a member of the IAS HIV Cure International Scientific Working Group, Associate Editor of Retrovirology and published over 150 original papers in peer reviewed journals and has guided many students, PhD students and Postdoctoral Fellows. 

Research groups

Translational virology

Research aim

By integrating insights from clinical and fundamental research on drug resistance, viral persistence, and evolution, we aim to improve antiviral treatment and viral eradication strategies globally

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Recent publications

Recommendations from the 2nd Consensus Workshop on Analytical Treatment Interruption in HIV Research Trials Thumbi Ndung'u, Krista L Dong, Donn J Colby, Steven G Deeks, Mark F Cotton, Karine Dubé, Philip J Goulder, Boris Julg, Moses Nsubuga, Gbolahan Ajibola, Katharine J Bar, Nomonde Bengu, Mutsa Bwakura-Dangarembizi, Marina Caskey, Gabriela Cromhout, Adeodata R Kekitiinwa, William Kilembe, Louise Kuhn, Udom Likhitwonnawut, Nyaradzo M Mgodi, Deborah Persaud, Michael J Peluso, Thomas A Rasmussen, Matthew Romo, Carlo Sacdalan, Wadzanai Samaneka, Roger Shapiro, Ole S Søgaard, Gareth Tudor-Williams, Charity Wambui, Randall Tressler, Sharon R Lewin, Trevor A Crowell, Victoria O Kasprowicz, Lydie Trautmann, , Monique Nijhuis
The lancet. HIV, 2026, vol. 13, p.e271-e281
Guidance on the clinical management of HIV-1 persistent low-level viraemia on antiretroviral treatment Tommaso Clemente, Arjen J Stam, Olof Elvstam, Anna Maria Geretti, Richard Harrigan, Milosz Parczewski, Nicola E Mackie, Vincenzo Spagnuolo, Marije Hofstra, Francois Venter, Daniel R Kuritzkes, Josep M Llibre, Robert W Shafer, Jonathan Schapiro, Esteban Martinez, Cissy Kityo-Mutuluuza, Monique Nijhuis, Per Björkman, Charlotte Charpentier, Simon Collins, Huldrych F Günthard, Diego Cecchini, Antonella Castagna, Nele Brusselaers, Annemarie Mj Wensing,
The lancet. HIV, 2026, vol. 13, p.e502-e514
HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir Pien Margien van Paassen, Alexander O Pasternak, Dita C Bolluyt, Karel A van Dort, Ad C van Nuenen, Irma Maurer, Brigitte Boeser-Nunnink, Ninée V E J Buchholtz, Tokameh Mahmoudi, Cynthia Lungu, Reinout van Crevel, Casper Rokx, Jori Symons, Monique Nijhuis, Annelou L I P van der Veen, Liffert Vogt, Michelle J Klouwens, Jan M Prins, Neeltje A Kootstra, Godelieve J de Bree
eLife, 2026, vol. 14
Causes of death in adults living with HIV in South Africa Tanvier Omar, Nadia Sabet, Alistair Calver, Gajendra Chita, Lucas E Hermans, Willem D F Venter, Adriaan Basson, Monique Nijhuis, Annemarie Wensing, Neil Martinson, Maria Papathanasopoulos, Ebrahim Variava
Southern African Journal of HIV Medicine, 2025, vol. 26
The imperative for increased investment for an HIV cure Remko van Leeuwen, Françoise Barré-Sinoussi, Michaela Müller-Trutwin, Asier Sáez-Cirión, Monique Nijhuis, Sharon R. Lewin, Thumbi Ndung'u, Florence Riako-Anam, Mitchell Warren, Izukanji Sikazwe, Birgit Poniatowski, Beatriz Grinsztejn, Cissy Kityo, Masen Davis, Ole S. Søgaard, Marcus Altfeld, Javier Martinez-Picado, Linos Vandekerckhove, Andrea Gramatica, Devin Sok, Simon Collins, Yazdan Yazdanpanah
The Lancet HIV, 2025, vol. 12, p.e671-e673
The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness Jori Symons, Claire Chung, Bert M Verheijen, Sarah J Shemtov, Dorien de Jong, Gimano Amatngalim, Monique Nijhuis, Marc Vermulst, Jean-Francois Gout
Nature Communications, 2025, vol. 16

External positions

Honorary Professor - Co-supervisie van PhD student, gastcolleges of seminars, gezamenlijke subsidie aanvragen/projecten - University of the Witwatersrand