Profile photo Monique Nijhuis

Monique Nijhuis

Associate Professor

Strategic program(s):

Biography

Monique Nijhuis obtained her PhD in 1999 at the University of Utrecht on the investigation of the impact of antiretoviral resistance on HIV fitness. Following postdoctoral research training in the US she initiated a research line at the interface between fundamental and clinical research and became an honourable Profssor of the University of the Witwatersrand in Johannesburg and an Associate Professor of Virology at the University Medical Center in Utrecht, the Netherlands. Her research interest are centred on (1) HIV reservoirs and eradication and (2) HIV drug resistance and evolution. She is heading the international multidisciplinary Spiral consortium investigating HIV cure strategies with a specific focus on sub-Saharan Africa, is a member of the IAS HIV Cure International Scientific Working Group, Associate Editor of Retrovirology and published over 150 original papers in peer reviewed journals and has guided many students, PhD students and Postdoctoral Fellows. 

Research groups

Translational virology

Research aim

By integrating insights from clinical and fundamental research on drug resistance, viral persistence, and evolution, we aim to improve antiviral treatment and viral eradication strategies globally

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Recent publications

The imperative for increased investment for an HIV cure Remko van Leeuwen, Françoise Barré-Sinoussi, Michaela Müller-Trutwin, Asier Sáez-Cirión, Monique Nijhuis, Sharon R. Lewin, Thumbi Ndung'u, Florence Riako-Anam, Mitchell Warren, Izukanji Sikazwe, Birgit Poniatowski, Beatriz Grinsztejn, Cissy Kityo, Masen Davis, Ole S. Søgaard, Marcus Altfeld, Javier Martinez-Picado, Linos Vandekerckhove, Andrea Gramatica, Devin Sok, Simon Collins, Yazdan Yazdanpanah
The Lancet HIV, 2025, vol. 12, p.e671-e673
The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness Jori Symons, Claire Chung, Bert M Verheijen, Sarah J Shemtov, Dorien de Jong, Gimano Amatngalim, Monique Nijhuis, Marc Vermulst, Jean-Francois Gout
Nature Communications, 2025, vol. 16
Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue Marieke M Nühn, Stephanie B H Gumbs, Pauline J Schipper, Irene Drosou, Lavina Gharu, Ninée V E J Buchholtz, Gijsje J L J Snijders, Frederieke A J Gigase, Annemarie M J Wensing, Jori Symons, Lot D de Witte, Monique Nijhuis
Viruses, 2025, vol. 17
Correction to Jord C Stam, Steven de Maat, Dorien de Jong, Mathia Arens, Fenna van Lint, Lavina Gharu, Mark H van Roosmalen, Rob C Roovers, Nika M Strokappe, Ralf Wagner, Alexander Kliche, Hans J de Haard, Paul M van Bergen En Henegouwen, Monique Nijhuis, C Theo Verrips
Scientific Reports, 2025, vol. 15
Model-based evaluation of the impact of a potential HIV cure on HIV transmission dynamics Alfredo De Bellis, Myrthe S Willemsen, Giorgio Guzzetta, Ard van Sighem, Kim A G J Romijnders, Peter Reiss, Maarten F Schim van der Loeff, Janneke H H M van de Wijgert, Monique Nijhuis, Mirjam E E Kretzschmar, Ganna Rozhnova
Nature Communications, 2025, vol. 16
Selective Decline of Intact HIV Reservoirs During the First Decade of ART Followed by Stabilization in Memory T Cell Subsets Marieke M. Nühn, Kobus Bosman, Terry Huisman, Wouter H.A. Staring, Lavina Gharu, Dorien D.E. Jong, Theun M. de Kort, Ninée V.E.J. Buchholtz, Kiki Tesselaar, Aridaman Pandit, Joop Arends, Sigrid A. Otto, Eduardo LUCIO D.E. Esesarte, Andy I.M. Hoepelman, Rob J. de Boer, Jori Symons, José A.M. Borghans, Annemarie M.J. Wensing, Monique Nijhuis
AIDS, 2025, vol. 39, p.798-811

External positions

Honorary Professor - Co-supervisie van PhD student, gastcolleges of seminars, gezamenlijke subsidie aanvragen/projecten - University of the Witwatersrand