Profile photo Nico Wulffraat

Nico Wulffraat

Full Professor

Biography

Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

Recent publications

Defining pain trajectories in juvenile arthritis and associated patient characteristics Maarten O Mensink, Sytze de Roock, Julia Drylewicz, Kevin Jenniskens, Nico Wulffraat, Joost F Swart, Niels Eijkelkamp
Arthritis research & therapy, 2026, vol. 28
Work productivity and activity impairment in patients under 18 with juvenile idiopathic arthritis (JIA) Deborah A Marshall, Rodrigo Dal Ben, Gillian R Currie, Rae S M Yeung, Sebastiaan J Vastert, Nico Wulffraat, Joost F Swart, Susanne Benseler,
Arthritis research & therapy, 2026, vol. 28
Development and Qualitative Evaluation of a Decision Support Tool for Withdrawal of Biologic Therapy in Nonsystemic Juvenile Idiopathic Arthritis Janine A van Til, Michelle M A Kip, Robert Marinescu-Muster, Karin Groothuis-Oudshoorn, Gillian R Currie, Susanne M Benseler, Joost F Swart, Sebastiaan J Vastert, Nico Wulffraat, Rae S M Yeung, Deborah A Marshall, Maarten J IJzerman
MDM policy & practice, 2025, vol. 10, p.23814683251364199
Effect of Time to Start of Biologic Therapy on Treatment Response in Childhood Arthritis Jelleke B. de Jonge, Sytze de Roock, Dieneke Schonenberg-Meinema, J. Merlijn van den Berg, Deborah A. Marshall, Sebastiaan J. Vastert, Rae S.M. Yeung, Joost F. Swart, Susanne M. Benseler, Adam Huber, Bianca Lang, Chelsea DeCoste, Elizabeth Stringer, Suzanne Ramsey, Alan Rosenberg, Kate Neufeld, Mehul Jariwala, Tristan Kerr, Alexander Mosoiu, Alisa Rachlis, Amy Xu, Arthur Cheng, Brenleigh Jebb, Brian Feldman, Bruno Pereira, Deborah Levy, Dilan Dissanayake, Elizaveta Limenis, Evelyn Rozenblyum, Harper Cheng, Jennifer Ji Young Lee, Lynn Spiegel, Rayfel Schneider, Ronald Laxer, Ruud Verstegen, Shirley Tse, Trang Duong, Andrea Human, David Cabral, Herman Tam, Jaime Guzman, Kim Morishita, Annet van Royen-Kerkhof, Berent Prakken, Erika Van Nieuwenhove, Marc Jansen, Nico Wulffraat, Elizabeth Legger, Ellen Schatorje, Michelle Kip,
Arthritis & Rheumatology, 2025, vol. 78, p.743-751
Systematic literature review informing the EULAR points to consider for patient education in physical activity and self-management of pain during transitional care Javier Courel-Ibáñez, Rafael Prieto-Moreno, Erica Briones-Vozmediano, Patrocinio Ariza-Vega, Saskya Angevare, Jordi Anton, Ilaria Bini, Daniel Clemente, Matilde Correia, Wendy Costello, Diederik De Cock, Andrea Domjan, Leticia Leon, Andrea Marques, Kirsten Minden, Ana Filipa Mourão, Aurelie Najm, Seza Özen, Georgina Pimentel, Zainab Saleem, Tomas Vetrovsky, Nico Wulffraat, Andrea Zacarias, Yeliz Prior, Loreto Carmona, Fernando Estévez-López
Annals of the rheumatic diseases, 2025, vol. 84, p.2115-2127
Clinical efficacy of SARS-CoV-2 Omicron-neutralizing antibodies in immunoglobulin preparations for the treatment of agammaglobulinemia in patients with primary antibody deficiency Michael Karbiener, Gerhard Kindle, Isabelle Meyts, Mikko R.J. Seppänen, Fabio Candotti, Marta Kamieniak, Reinhard Ilk, Thomas R. Kreil, Markus G. Seidel, Dalia Abd Elaziz, Lofty M. Abdelkader Sohilla, Avigaelle Abitbol, Abolhassani Hassan, Lalash Abrahim, Mohamed Abuzakouk, Moussouni Nabila Achir, Veronica Afonso, Philipp Agyeman, Martina Ahlmann, Alessandro Aiuti, Abla Akl, Güzide Aksu, Kim Albers, Michael Albert, Meda Diana Alecsandru, Olga Aleinikova, Svetlana Aleshkevich, Luis Allende, Mickael Alligon, Zoe Allwood, Manrique de Lara Laia Alsina, Daniela Ambrosch‐barsoumian, Lisa Ameshofer, Kenza Amour, Evrim Anadol, Ariharan Ananthachagaran, Chantal Andriamanga, Julia Andris, Karin Andritschke, Federica Angelini, Tobias Ankermann, Jaap Jan Boelens, P. M. Ellerbroek, Lucy Gossens, Ellen Schatorje, Annick van de Ven, Michiel van der Flier, J. M. van Montfrans, Annet van Royen-Kerkhof, Nico M. Wulffraat,
Journal of Medical Virology, 2024, vol. 96

Fellowships & Awards

FP7 Grant Pharmachild

AEMC Grant SHARE

Div. ZON MW Grants

UCAN CANDU

Foreum

AbbVie (bijdrage Reuma2Go)

Roche (bijdrage Reuma2Go)

ERN coordinator RITA

ZonMW grant Chronic Fatique QFS and JIA

External positions

chair of the European rare Diseases Network (RITA) - Clinical & Research expertise - The European Reference Network