Profile photo Neeltje Steeghs

Neeltje Steeghs

Full Professor

Strategic program(s):

Biography

Neeltje Steeghs, M.D., Ph.D. is a licensed Medical Oncologist and Clinical Pharmacologist.  She served as chair of the Dutch Pharmacology Oncology Group and chair of the Dutch GIST consortium. Her main scientific interests are new drug development, including the  performance of clinical phase I and early phase II trials, and the inclusion of pharmacokinetics and pharmacodynamics in these studies. She also has a major interest in the design aspects of early clinical studies.
Besides her clinical activities, she has been Clinical Assessor for the Medicines Evaluation Board of the European Medicines Agency (2009-2011), chair of the Dutch Sarcoma Study Group, board member for the Paediatric Oncology Research Foundation (2010-2013), Young investigator for the EORTC Soft Tissue and Bone Sarcoma Group (2013-2016), chair of the multidisciplinary expert board for the Center for Personalized Cancer Treatment (2012-2015) and Vice-Chair of the Medical Ethical Committee of the Netherlands Cancer Institute. She has also been board member for the Dutch Oncological Medicine Evaluation Board, the National Working Party for Cancer Drugs Interactions and the Translational Research Board of the Netherlands Cancer Institute. She has a.o. been editor of Gastrointestinal Stromal Tumor (GIST), and Pharmacology of Anti-Cancer Drugs.
She currently serves as Director for the National Platform of Early Phase Clinical Trials at Oncode Accelerator/University Medical Center Utrecht, as Director of the Early Drug Development Center and Clinical Research at the Netherlands Cancer Institute, in Amsterdam, the Netherlands and as advisor for several pharmaceutical companies.
Neeltje Steeghs has been principle investigator for many investigator initiated and industry sponsored clinical trials. She is regarded as a leading authority on mechanisms for safe and effective dosing of anticancer agents. She has authored or co-authored over 200 scientific papers, and has given numerous lectures on a variety of topics at international meetings.
Neeltje Steeghs was invited to join the ESMO 2024 Scientific Committee as member of the Developmental therapeutics track.

Strategic program(s):

Contact

Recent publications

The impact of pazopanib and extremity radiotherapy on transaminase elevations in soft tissue sarcoma Bauke H G Van Riet, Shermarke Hassan, Thomas R De Wijkerslooth, Tom T P Seijkens, Alwin D R Huitema, Neeltje Steeghs, Rick L Haas
Acta oncologica (Stockholm, Sweden), 2026, vol. 65, p.641-651
The use of pharmacodynamic results for recommended phase II decision making in oncology clinical trials A C Kanhailal, M J J Lucassen, T Schutte, W Zwart, A D R Huitema, N Steeghs
Cancer chemotherapy and pharmacology, 2026, vol. 96
ASO Visual Abstract Tessa van Amerongen, Emily I Holthuis, Deborah van de Wal, Dide den Hollander, Ingrid M E Desar, Hans Gelderblom, Astrid W Oosten, Anna K L Reyners, Neeltje Steeghs, Joost S Groen, Winette T A van der Graaf, Olga Husson
Annals of surgical oncology, 2026, vol. 33, p.7383-7384
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of cergutuzumab amunaleukin U Lassen, E M J van Brummelen, I Melero, E Angevin, H Joensuu, N H Segal, M Mau-Sørensen, N Steeghs, M E Rodríguez-Ruiz, K Homicsko, J Tabernero, M Cañamero, D Dejardin, C Habigt, E Rossmann, E Guarin, G Babitzki, H E S Baumann, A P Silva, C Adessi, C Boetsch, S Evers, J Charo, V Teichgräber, G Argilés
ESMO open, 2026, vol. 11
The SHERPA trial Ashwini C Kanhailal, Jonathan E Knikman, Sybrand W J Zielhuis, Liudmila L Kodach, René Bernards, Alwin D R Huitema, Matthijs Tibben, Emile E Voest, Brent M Gerrits, Hinke Huisman-Siebinga, Neeltje Steeghs, Sara Mainardi, Frans L Opdam
European Journal of Cancer, 2026, vol. 241
Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors Neeltje Steeghs, Carlos Gomez-Roca, Iphigénie Korakis, Eelke Gort, Hilde De Winter, Nina Stojcheva, Vaia Stavropoulou, Jennifer Krieg, Paul Baverel, Elena Fernandez, Ana Maria Florescu, Lea Hoenig, Michael Peter Sanderson, Vladimir Kirkin, Philippe Legenne, Philippe Alexandre Cassier
Nature Cancer, 2026, vol. 7, p.810-822

External positions

lid portfolio review board - 1x per 2 jaar portfolio review - Cancer Research UK Center for Drug Development

Internist-oncoloog/hoofd CRU - Internist-oncoloog/hoofd CRU - Nederlands Kanker Instituut - Antoni van Leeuwenhoek

editor - editor - Journals (meerdere)

Consultancy - Advisering tav medicijn ontwikkeling en klinische studies - Meerdere farmaceutische bedrijven

Lid - Beoordeling studievoorstellen - METC