Profile photo Moons


Full Professor

Strategic program(s):


K.G.M. (Carl) Moons is Professor of Clinical Epidemiology at the Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. He is Director of Research of the Julius Center (550 Employees). He headed the research program ‘Research Methodology’ until 2019. 


- MSc in Biomedical Sciences (Radboud University Nijmegen, 1992);

- MSc in Clinical Epidemiology (Erasmus University Rotterdam, 1994)

- PhD in Medicine (Erasmus University Rotterdam, 1996).

Since 2005 full Professor of Clinical Epidemiology at the Julius Center,UMC Utrecht, Utrecht University, Utrecht, The Netherlands.

He was a visiting Professor at the University of Virginia, USA (2002) and at Tokai University, Japan (2005-2010).

He has been a member of various committees, e.g. Netherlands Organization for Scientific Research, Royal Dutch Academy of Sciences, Dutch Health Council, Cochrane Collaboration, and Medical Ethical Committees.

He is principal investigator in numerous international clinical (epidemiology) studies funded by various organisations (EU, NHS, NIH). His experience covers the full range of conduct, data analysis, reporting and dissemination of such studies, varying from studies on the evaluation of medical devices and tests for diagnosis, prognosis, screening and monitoring, to etiological studies and randomised therapeutic trials, to meta-epidemiological studies, both on aggregate and individual participant data. His main focus concerns improving the methods and approaches for evaluation and implementation of medical devices, (bio)markers and prediction models. His major expertise is introducing innovations for the design, conducting, analysis and reporting of evaluations of diagnostic and prognostic tests, devices, (bio)markers and prediction models. Clinical topics include cancer, deep vein thrombosis, stroke, heart failure and peri-operative risk assessment. He teaches graduate and postgraduate students in all aspects of clinical (epidemiological) research design, conducting, analysis and reporting, throughout the world.

Indicators of Research Excellence

Over his career Professor Moons has published over 480 peer-reviewed publications (including scientific papers and book chapters) with >22,000 citations (H index 72, Scopus). He has obtained numerous (methodological and applied) research grants, including large prestigious personal grants (in summary over 10 million euro as co-PI). The (societal) impact of his research record has also been recognised by membership of the Dutch Health Council, Chair of Committee of the Royal Netherlands Academy of Arts and Sciences, membership of numerous committees of Dutch Scientific Organisations, and interviews for national and internal news magazines. He also teaches bachelor, master, post doctoral students in clinical research across the world, including Asia and Africa.


Strategic program(s):


Recent publications

Managing the Increasing Burden of Atrial Fibrillation through Integrated Care in Primary Care Carline J van den Dries, Miriam P van der Meulen, Geert W J Frederix, Arno W Hoes, Karel G M Moons, Geert-Jan Geersing
International Journal of Integrated Care, 2023, vol. 23
Dual hormone fully closed loop in type 1 diabetes Milena Jančev, Frank J. Snoek, Geert W.J. Frederix, Heleen Knottnerus, Helga Blauw, Maureen Witkop, Karel G.M. Moons, Arianne C. Van Bon, J. Hans Devries, Erik H. Serné, Thomas T. Van Sloten, Harold W. De Valk
BMJ Open, 2023, vol. 13
Accuracy of physicians' intuitive risk estimation in the diagnostic management of pulmonary embolism Rosanne van Maanen, Emily S L Martens, Toshihiko Takada, Pierre-Marie Roy, Kerstin de Wit, Sameer Parpia, Noémie Kraaijpoel, Menno V Huisman, Philip S Wells, Grégoire Le Gal, Marc Righini, Yonathan Freund, Javier Galipienzo, Nick van Es, Jeanet W Blom, Karel G M Moons, Frans H Rutten, Maarten van Smeden, Frederikus A Klok, Geert-Jan Geersing, Kim Luijken
Journal of thrombosis and haemostasis : JTH, 2023, vol. 21, p.2873-2883
Propensity-based standardization to enhance the validation and interpretation of prediction model discrimination for a target population Valentijn M.T. de Jong, Jeroen Hoogland, Karel G.M. Moons, Richard D. Riley, Tri Long Nguyen, Thomas P.A. Debray
Statistics in Medicine, 2023, vol. 42, p.3508-3528
Increased endorsement of TRIPOD and other reporting guidelines by high impact factor journals Pauline Heus, Demy L Idema, Emma Kruithof, Johanna Aag Damen, Maud S Verhoef-Jurgens, Johannes B Reitsma, Karel Gm Moons, Lotty Hooft
Journal of Clinical Epidemiology, 2023, vol. 165
The relation between prediction model performance measures and patient selection outcomes for proton therapy in head and neck cancer Artuur Marijn Leeuwenberg, Johannes Bernardus Reitsma, Lisa Griet Lydia Jozef Van den Bosch, Jeroen Hoogland, Arjen van der Schaaf, Frank Jozef Pieter Hoebers, Oda Bemadette Wijers, Johannes Albertus Langendijk, Karel Gerardus Maria Moons, Ewoud Schuit
Radiotherapy and Oncology, 2023, vol. 179

Fellowships & Awards

2010: Personal (VICI) award

2009: Methoden voor diagnostische test evaluaties

2008: TOP Grant

2003: Personal (VIDI) award

2003: Verbetering voorspelling diagnose

External positions

Adjunct Professor, Univ Oxford, University of Oxford, Dept Stat

Adjunct Professor, Vanderbilt Univ, Vanderbilt University, Dept Biostat