Profile photo Monique Minnema

Monique Minnema

Full Professor

Strategic program(s):


Prof Dr Monique Minnema was trained as internist and hematologist at Academic Medical Center, Amsterdam and the University Medical Center, Utrecht. She started working as a hematologist in 2005 at the department of hematology, UMC Utrecht and was appointed full professor in 2019. She is specialized in the diagnosis and treatment of B cell malignancies, especially plasma cell dyscrasis  like Multiple Myeloma and AL amyloidosis, and Waldenstrom Macroglobulinemia. Prof Minnema is author on several national and internatonial quidelines on the diagnosis and treatment of these diseases.
She is head supervisor of the hematology clinical research team, the hematology biobank and the European expertise reference network (ERN) malignant hematology of the UMC Utrecht. Her main focus of clinical research is the development of novel therapies (both cellular and drug) developments for plasma cell dyscrasias. 

Prof Dr Minnema is an active member of the HOVON working parties for Multiple
Myeloma, Lymphoma, IEC and the vice president of the Lunenburg Lymphoma consortium (LLPC) for phase I/II studies. Examples of her work are the HOVON 104 trial for patients with AL amyloidosis first line treatment, the clinical studies with the monoclonal antibody Daratumumab in relapsed Multiple Myeloma and newly diagnosed AL amyloidosis and anti CD19 CAR T cells in relapsed Lymphoma.
Her translational research focuses on 3D models to predict response to therapy and the use of combined immunotherapy for relapsed multiple myeloma.

She was a member of the organizing committee of the Waldenström workshop in Amsterdam in 2016, and is co initiator of the yearly Immune Effector Cell and the Systemic Amyloidosis symposia. 

Research groups

B cell malignancies

Research aim

Our research aim is to control cellular life and death decisions to improve treatment of B cell cancers and allow T cell immunotherapy for untreatable cancers.
Go to group

Decision support systems for precision care in translational cancer-imaging

Research aim

To develop, validate and implement decision support systems based on imaging for the diagnosis, prognosis and triaging of oncology patients
Go to group

Recent publications

Healthcare Resource Utilization and Cost-of-Illness in Systemic Light Chain (AL) Amyloidosis in Europe Arnaud Jaccard, Frank Bridoux, Wilfried Roeloffzen, Monique C Minnema, Rui Bergantim, Roman Hájek, Cristina João, M Teresa Cibeira, Giovanni Palladini, Stefan Schönland, Giampaolo Merlini, Paolo Milani, Meletios A Dimopoulos, Sriram Ravichandran, Ute Hegenbart, Hermine Agis, Blanca Gros, Aisha Asra, Valeria Magarotto, Giorgos Cheliotis, Giorgos Psarros, Pieter Sonneveld, Ashutosh Wechalekar, Efstathios Kastritis
Clinical Lymphoma, Myeloma and Leukemia, 2024, vol. 24, p.e205-e216
Identifying clinical response to daratumumab therapy in relapsed/refractory multiple myeloma using a patient-derived in vitro model Niels van Nieuwenhuijzen, Marta Cuenca, Leonie Abbink, Margot Jak, Victor Peperzak, Monique C Minnema
EJHaem, 2024, vol. 5, p.141-146
Bispecific Antibody Use in Patients With Lymphoma and Multiple Myeloma Adam Braun, Sushanth Gouni, Astrid Pulles, Paolo Strati, Monique C Minnema, Lihua E Budde
American Society of Clinical Oncology educational book , 2024, vol. 44
Primary cerebral immunoglobulin light chain amyloidoma in a patient with multiple sclerosis Marissa J M Traets, Krisna Chuwonpad, Roos J Leguit, Stephan T F M Frequin, Monique C Minnema
BMJ Case Reports, 2024, vol. 17
Long-term outcomes of patients with large B-cell lymphoma treated with axicabtagene ciloleucel and prophylactic corticosteroids Olalekan O Oluwole, Edouard Forcade, Javier Muñoz, Sophie de Guibert, Julie M Vose, Nancy L Bartlett, Yi Lin, Abhinav Deol, Peter McSweeney, Andre H Goy, Marie José Kersten, Caron A Jacobson, Umar Farooq, Monique C Minnema, Catherine Thieblemont, John M Timmerman, Patrick Stiff, Irit Avivi, Dimitrios Tzachanis, Yan Zheng, Saran Vardhanabhuti, Jenny Nater, Rhine R Shen, Harry Miao, Jenny J Kim, Tom van Meerten
Bone Marrow Transplantation, 2024, vol. 59, p.366-372
Biomarker analysis of the ASPEN study comparing zanubrutinib with ibrutinib for patients with Waldenström macroglobulinemia Constantine S Tam, Stephen Opat, Shirley P D'Sa, Wojciech Jurczak, Hui-Peng Lee, Gavin Cull, Roger G Owen, Paula Marlton, Björn E Wahlin, Ramon Garcia-Sanz, Helen McCarthy, Stephen P Mulligan, Alessandra Tedeschi, Jorge J Castillo, Jaroslaw Czyz, Carlos Fernández de Larrea, David Belada, Edward N Libby, Jeffrey V Matous, Marina Motta, Tanya Siddiqi, Monica Tani, Marek Trněný, Monique C Minnema, Christian Buske, Véronique Leblond, Steven P Treon, Judith Trotman, Binghao Wu, Yiling Yu, Zhirong Shen, Wai Y Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Meletios-Athanasios A Dimopoulos
Blood Advances, 2024, vol. 8, p.1639-1650

Fellowships & Awards

2017: Dutch Cancer Society/KWF Research Project: Personalized strategy to avert drug resistance in hematologic cancers.