Profile photo Minke Rab

Minke Rab

Research Staff Other

Strategic program(s):

Biography

Dr. Minke Rab is a Clinical Scientist, who graduated from medical school in 2010 after completing the Selective University Medical Masters (SUMMA) program at the UMCU, The Netherlands. In 2015 she started her PhD project on hereditary hemolytic anemias (UMCU, 2015-2019). After her internal medicine residency, she completed a two-year fellowship in Hematology (UMCU) while combining her clinical work with laboratory research. Thereafter, she has been appointed as hematologist at the Erasmus University Medical Center Rotterdam, where she is involved in the expertise center for hemoglobinopathies. Next to her clinical work, she works as assistant professor at the Central Diagnostic Laboratory-Research, UMCU on biomarker development in hereditary hemolytic anemias. A key achievement is the development of oxygenscan-related biomarkers reflecting RBC sickling on which she co-authored nine papers. She led the development of the oxygenscan from an early prototype stage into a technique that is now incorporated in various clinical trials in the US, Europe, and Africa.

Her research focusses on biomarker development in sickle cell disease and its applicability to assess novel therapies both in vitro and in vivo. For these kind of projects funding was obtained from Eurostars, RVO, Agios pharmaceuticals, Axcella Health and RR Mechatronics. It is the ambition of dr. Rab to further elucidate the crucial pathophysiological features of sickle cell disease, in order to find the best treatment, that is globally available, for this understudied disorder. Being a clinician-scientist, she is in an excellent position to bridge the gap between bench and bedside.

Recent publications

Cryopreservation of Red Blood Cells From Sickle Cell Disease Patients for Comparison of Oxygen Gradient Ektacytometry Parameters Between Laboratories to Enable Data Harmonization Marissa J M Traets, Amira Idrizovic, Jennifer Eijkelenboom-Bos, Martijn Veldthuis, Menno van der Hoorn, Myrthe J van Dijk, Romee Balvert, Mirco D'Agnolo, Mickaël Marin, Emmanuelle Bourdelier, Emmanuel Adu, Nicolas Hebert, Pablo Bartolucci, Maria Paola Boaro, Mariane de Montalembert, Raffaella Colombatti, Vivien A Sheehan, Eduard J van Beers, Richard van Wijk, María Del Mar Mañú-Pereira, Rob van Zwieten, Minke A E Rab
International Journal of Laboratory Hematology, 2026, vol. 48, p.900-905
Oxidantscan C A Hernández, M J M Traets, W W van Solinge, A W Rijneveld, L Kaestner, T John, E Nur, B J Biemond, F A Kuypers, E J van Beers, M A E Rab, R van Wijk
Blood Cells, Molecules, & Diseases, 2025, vol. 117
Metabolomics in sickle cell disease Sigrid van der Veen, Judith J.M. Jans, Eduard J. van Beers, Bart J. Biemond, Pablo Bartolucci, Maria Paola Boaro, Anna Collado Gimbert, Raffaella Colombatti, Mirco D'Agnolo, Karin J. Fijnvandraat, Amira Idrizovic, Petros Kountouris, Mar Mañú Pereira, Elisabetta Mezzalira, Minke A.E. Rab, Anita W. Rijneveld, Tiziana Sanavia, Nanda M. Verhoeven-Duif, Marjon H. Cnossen
Blood Reviews, 2025, vol. 74
Iron Deficiency in HbSC Disease Treated With Repetitive Phlebotomy Is Associated With Fewer Sickle Cell Disease-Related Complications Marissa J M Traets, Aida S Kidane Gembremeskel, Jennifer Eijkelenboom-Bos, Birgitte A van Oirschot, Sigrid van der Veen, Henk Russcher, Wouter W van Solinge, Mandy N Lauw, Erfan Nur, Bart J Biemond, Marjon H Cnossen, Anita W Rijneveld, Richard van Wijk, Eduard J van Beers, Minke A E Rab
American journal of hematology, 2025, vol. 100, p.2123-2127
The use of race and ethnicity in sickle cell disease research Aida S Kidane Gebremeskel, Minke A Rab, Erik D van Werkhoven, Teun B Petersen, Marjon H Cnossen, Amade M'charek, Karlijn A C Meeks, Anita W Rijneveld
BMC Medical Research Methodology, 2025, vol. 25, p.1-10
Red blood cell pyruvate kinase properties in Townes and Berkeley sickle cell disease mouse models – Of mice and men Marissa J.M. Traets, Titine J.J. Ruiter, Charles Levine, Anita W. Rijneveld, Judith J. Jans, Carsten Alt, Minke A.E. Rab, Yu Wei Chen, Richard van Wijk, Brigitte A. van Oirschot
Blood Cells, Molecules, and Diseases, 2025, vol. 111

External positions

Internist-Hematoloog - Aanstelling als Internist-Hematoloog - Erasmus MC Rotterdam