Profile photo Minke Rab

Minke Rab

Assistant Professor

Strategic program(s):

Biography

Dr. Minke Rab is a Clinical Scientist, who graduated from medical school in 2010 after completing the Selective University Medical Masters (SUMMA) program at the UMCU, The Netherlands. In 2015 she started her PhD project on hereditary hemolytic anemias (UMCU, 2015-2019). After her internal medicine residency, she completed a two-year fellowship in Hematology (UMCU) while combining her clinical work with laboratory research. Thereafter, she has been appointed as hematologist at the Erasmus University Medical Center Rotterdam, where she is involved in the expertise center for hemoglobinopathies. Next to her clinical work, she works as assistant professor at the Central Diagnostic Laboratory-Research, UMCU on biomarker development in hereditary hemolytic anemias. A key achievement is the development of oxygenscan-related biomarkers reflecting RBC sickling on which she co-authored nine papers. She led the development of the oxygenscan from an early prototype stage into a technique that is now incorporated in various clinical trials in the US, Europe, and Africa.

Her research focusses on biomarker development in sickle cell disease and its applicability to assess novel therapies both in vitro and in vivo. For these kind of projects funding was obtained from Eurostars, RVO, Agios pharmaceuticals, Axcella Health and RR Mechatronics. It is the ambition of dr. Rab to further elucidate the crucial pathophysiological features of sickle cell disease, in order to find the best treatment, that is globally available, for this understudied disorder. Being a clinician-scientist, she is in an excellent position to bridge the gap between bench and bedside.

Recent publications

Biallelic hexokinase 1 (HK1) variants causative of non-spherocytic haemolytic anaemia Elli-Maija Ukonmaanaho, Silvia Dell'Anna, Anna Hakonen, Ulla Wartiovaara-Kautto, Sakari Kakko, Minke A E Rab, Brigitte van Oirschot, Minna Kraatari-Tiri, Richard van Wijk, Elisa Rahikkala
British Journal of Haematology, 2024, vol. 204, p.2040-2048
A novel composition of endogenous metabolic modulators improves red blood cell properties in sickle cell disease Myrthe J van Dijk, Marissa J M Traets, Brigitte A van Oirschot, Titine J J Ruiter, Jonathan R A de Wilde, Jennifer Bos, Wouter W van Solinge, Margaret J Koziel, Judith J M Jans, Revati Wani, Eduard J van Beers, Richard van Wijk, Minke A E Rab
EJHaem, 2024, vol. 5, p.21-32
Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease Myrthe J van Dijk, Titine J J Ruiter, Sigrid van der Veen, Minke A E Rab, Brigitte A van Oirschot, Jennifer Bos, Cleo Derichs, Anita W Rijneveld, Marjon H Cnossen, Erfan Nur, Bart J Biemond, Marije Bartels, Roger E G Schutgens, Wouter W van Solinge, Judith J M Jans, Eduard J van Beers, Richard van Wijk
Hemasphere, 2024, vol. 8
Activation of pyruvate kinase as therapeutic option for rare hemolytic anemias Myrthe J van Dijk, Jonathan R A de Wilde, Marije Bartels, Kevin H M Kuo, Andreas Glenthøj, Minke A E Rab, Eduard J van Beers, Richard van Wijk
Blood Reviews, 2023, vol. 61
A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia Myrthe J. van Dijk, Brigitte A. van Oirschot, Alexander N. Harrison, Steffen M. Recktenwald, Min Qiao, Amaury Stommen, Anne Sophie Cloos, Juliette Vanderroost, Romano Terrasi, Kuntal Dey, Jennifer Bos, Minke A.E. Rab, Anna Bogdanova, Giampaolo Minetti, Giulio G. Muccioli, Donatienne Tyteca, Stéphane Egée, Lars Kaestner, Robert S. Molday, Eduard J. van Beers, Richard van Wijk
American Journal of Hematology, 2023, vol. 98, p.1877-1887
Use of the oxygen gradient ektacytometry in the dose titration of hydroxyurea therapy in children with sickle cell disease Maite E Houwing, Jennifer Bos, Richard van Wijk, Eduard J van Beers, Marjon H Cnossen, Minke A E Rab,
International Journal of Laboratory Hematology, 2023, vol. 46, p.390-394