Profile photo Michal Mokry

Michal Mokry

Associate Professor

Strategic program(s):

Biography

In my research, I unravel the biological mechanisms behind atherosclerosis. I employ a combination of bulk and single-cell transcriptomics, epigenetics, and bioinformatics, and integrate these approaches with clinical datasets and in vitro experiments.

My work leverages the largest biobank of well-characterized atherosclerotic plaques from over 4,000 patients, known as the Athero-Express study. We generate a variety of complex “-omics” datasets, which include genotyping, transcriptomics (bulk, single-cell, and spatially resolved), DNA methylation (both bulk and single-cell), and proteomics. These datasets are integrated with histological and clinical data to decode the mechanisms of plaque pathogenesis. This integration enables us to pinpoint specific processes that lead to severe manifestations of atherosclerotic disease, such as stroke and myocardial infarction. Alongside computational tools, we utilize primary in vitro model systems derived from vascular and plaque cells, as well as molecular biology techniques, for validation and mechanistic studies."

Recent publications

Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans Ernest Diez Benavente, Robin J G Hartman, Tim R Sakkers, Marian Wesseling, Yannicke Sloots, Lotte Slenders, Arjan Boltjes, Barend M Mol, Gert J de Borst, Dominique P V de Kleijn, Koen H M Prange, Menno P J de Winther, Johan Kuiper, Mete Civelek, Sander W van der Laan, Steve Horvath, Charlotte Onland-Moret, Michal Mokry, Gerard Pasterkamp, Hester M den Ruijter
Arteriosclerosis, Thrombosis, and Vascular Biology, 2024, vol. 44, p.1419-1431
A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example M Wesseling, E Diez-Benavente, M Mokry, H M den Ruijter, G Pasterkamp
Vascular Pharmacology, 2024, vol. 154, p.1-5
CBP/P300 Inhibition Impairs CD4+ T Cell Activation Lucas Wilhelmus Picavet, Anoushka A K Samat, Jorg Calis, Lotte Nijhuis, Rianne Scholman, Michal Mokry, David F Tough, Rabinder K Prinjha, Sebastiaan J Vastert, Jorg van Loosdregt
Biomedicines, 2024, vol. 12
IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration Alessandro Cutilli, Suze A Jansen, Francesca Paolucci, Michal Mokry, Enric Mocholi, Caroline A Lindemans, Paul J Coffer
2024
Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species Juntao Fang, Qiangbing Yang, Renée G C Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P G Sluijter
Stem Cell Research & Therapy [E], 2024, vol. 15, p.19
Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior Suze A. Jansen, Alessandro Cutilli, Coco de Koning, Marliek van Hoesel, Cynthia L. Frederiks, Leire Saiz Sierra, Stefan Nierkens, Michal Mokry, Edward E.S. Nieuwenhuis, Alan M. Hanash, Enric Mocholi, Paul J. Coffer, Caroline A. Lindemans
iScience, 2024, vol. 27, p.1-19

Fellowships & Awards

2015: Career Development Grant