Miangela Lacle

Assistant Professor - medical

Strategic program(s):

Contact

m.m.lacle@umcutrecht.nl

Pure profile

Research groups

Pathology of gastrointestinal tract tumors

Research aim

Our aim is to increase understanding of the pathogenesis of gastrointestinal tract tumors and to identify and validate potential histopathological and molecular biomarkers to improve and personalize therapy for patients.

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Early (T1-T2) colorectal cancers

Research aim

To minimize the impact of treatment for early (T1-T2) colorectal cancers, while preserving the high survival rates, achieve the highest quality of life for patients, and lower the healthcare costs.

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Recent publications

All publications

Reliable and Efficient Tissue Segmentation in Whole-Slide Images Sander Elias Magnussen Helgesen, Anthony Manet, Karolina Cyll, Kari Anne Risan Tobin, Marna Lill Kjæreng, Ilyá Kostolomov, Audun Ljone Henriksen, Sepp de Raedt, Hanne Arenberg Askautrud, Miangela Lacle, Robert Jones, Cornelis Verhoef, Tarjei Sveinsgjerd Hveem, Ole Johan Skrede, Andreas Kleppe
Proceedings of Machine Learning Research, 2026, vol. 316, p.223-233

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers Julian R. Buissant des Amorie, Joris H. Hageman, Sascha R. Brunner, Suzanne E.M. van der Horst, Maria C. Puschhof, Arne van Hoeck, Inge van Lierop, Sjors Middelkamp, Lisa van der Schee, Sven van Kempen, Folkert Morsink, Robin Geene, Sander Mertens, David S. Cavigelli, Ingrid Verlaan-Klink, Lianne J. Kraaier, Jorieke Salij, Renate Bezemer, Onno Kranenburg, Miangela M. Laclé, Leon M.G. Moons, Hugo J.G. Snippert
Nature, 2026, vol. 654, p.229-239

Reliable classification of polyps based on artificial intelligence Frida M.I. Julbø, Audun L. Henriksen, Manohar Pradhan, Erika K. Lindstrøm, Ilyá Kostolomov, Dahmane Oukrif, Lisa van der Schee, Maria X. Isaksen, Anthony Manet, Ole Johan Skrede, Sepp De Raedt, Knut Liestøl, Hanne A. Askautrud, Tor J. Eide, Øyvind Holme, David J. Kerr, Neil A. Shepherd, Miangela M. Lacle, Marco Novelli, Tarjei Sveinsgjerd Hveem, Andreas Kleppe
EClinicalMedicine, 2026, vol. 93

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer William C H Cross, Salpie Nowinski, George D Cresswell, Maximilian Mossner, Abhirup Banerjee, Bingxin Lu, Marc J Williams, Georgios Vlachogiannis, Laura J Gay, Ann-Marie Baker, Christopher Kimberley, Frederick J H Whiting, Hayley L Belnoue-Davis, Pierre Martinez, Maria Traki, Viola Walther, Kane Smith, Javier Fernandez-Mateos, Erika Yara-Romero, Erica A Oliveira, Salvatore Milite, Giulio Caravagna, Chela T James, George Elia, Alison Berner, Chang-Ho Ryan Choi, Pradeep Ramagiri, Ritika Chauhan, Nik Matthews, Jamie Murphy, Anthony Antoniou, Susan K Clark, Miriam Mitchison, Jo-Anne Chin Aleong, Enric Domingo, Inmaculada Spiteri, Stuart A C McDonald, Darryl Shibata, Miangela M Laclé, Lai Mun Wang, Morgan Moorghen, Ian P M Tomlinson, Marco Novelli, Marnix Jansen, Alan Watson, Nicola Valeri, Nicholas A Wright, John A Bridgewater, Manuel Rodriguez-Justo, Chris P Barnes, Hemant M Kocher, Simon J Leedham, Andrea Sottoriva, Trevor A Graham
Cancer Discovery, 2026, vol. 16, p.218-234

Multiplex spatial omics reveals changes in immune-epithelial crosstalk during inflammation and dysplasia development in chronic IBD patients Matthijs J.D. Baars, Evelien Floor, Neeraj Sinha, José J.M. ter Linde, Stephanie van Dam, Mojtaba Amini, Isaäc J. Nijman, Joren R. ten Hove, Julia Drylewicz, G. Johan A. Offerhaus, Miangela M. Laclé, Bas Oldenburg, Yvonne Vercoulen
iScience, 2024, vol. 27