Madelon Maurice

Full Professor

Strategic program(s):

Biography

Strategic program(s):

Contact

mmaurice@umcutrecht.nl

Pure profile

Research groups

Cancer tissue organization, Cell-cell signaling, Organoid models, Mutational driver mechanisms, Targeted protein degradation

Research aim

We aim to 1) acquire a molecular understanding of how patient-derived mutations promote cancer development and progression, and 2) use our expertise and know-how in targeted protein degradation to develop improved cancer-targeting strategies.

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Recent publications

All publications

E3 ubiquitin-ligase Hakai regulates LRP4 stability and Wnt/β-catenin signalling in colorectal cancer cells Andrea Rodríguez-Alonso, Lía Jove, Gloria Alfonsín, Marta Tasende, Ingrid Jordens, Madelon Maurice, Angélica Figueroa
iScience, 2026, vol. 29

WNT7B drives a program for pancreatic cancer subtype switching and progression Joep Sprangers, Jeroen M. Bugter, Despina Xanthakis, Michiel Boekhout, Rutger N.U. Kok, Veerle E. Geurts, Hans Clevers, Lodewijk A.A. Brosens, Frederike Dijk, Maria J. Rodríguez Colman, Jelte Y. van der Vaart, Madelon M. Maurice
iScience, 2026, vol. 29

Hepatocellular carcinoma-linked AXIN1 mutations drive low Wnt/β-catenin activity enabling niche-independent growth and YAP/TAZ signaling Anton J Venhuizen, Yvanka van Os, Milo L Kaptein, Marleen T Aarts, Despina Xanthakis, Ingrid Jordens, Madelon M Maurice
iScience, 2026, vol. 29

WNK kinase regulates plasma membrane levels of the WNT inhibitor RNF43 Gabriele Colozza, Ingrid Jordens, Eric Sosa, Jeongmin Ha, Szu-Hsien Sam Wu, Katherina Tavernini, Andrea Català-Bordes, Fiona Farnhammer, Noelia Urbán, Madelon M Maurice, Bon-Kyoung Koo
2025

Intestinal LKB1 Loss Drives a Premalignant Program Along the Serrated Cancer Pathway S F Plugge, H Ma, J Y van der Vaart, J Sprangers, F H M Morsink, D Xanthakis, C Jamieson, K B W Stroot, A R Keijzer, T Margaritis, T Candelli, R Straver, J de Ridder, F C P Holstege, W W J de Leng, G J A Offerhaus, A Merenda, M M Maurice
Gastroenterology, 2025, vol. 170, p.298-314

BRAF^V600E augments WNT signaling in colorectal cancer via aberrant DNA methylation Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

Fellowships & Awards

UMCU-TKI grant 2023

KWF-TKI grant 2023

External positions

Chair of Scientific Advisory Board of Laigo Bio - Scientific advisory activities - Laigo Bio BV

Scientific advisor - Scientific advisory activities - Laigo Bio BV

Patent holder on inventive technology licensed to Laigo Bio BV - N/A - Laigo Bio BV

Grant Support ArgoBio - Ja - Grant support bij ArgoBio

Co-founder en shareholder bij Laigon Bio - Ja - Laigo Bio

Lid van research management committee bij Oncode Institute - Ja - Oncode Institute

Member of Research Council KWF - Ja - KWF