Profile photo Marc Bonten

Marc Bonten

Full Professor

Strategic program(s):

Biography

Marc Bonten earned his MD (1991) and PhD (“the role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia, 1994) at the Maastricht University Medical School, the Netherlands. He registered as internist in 2000, as infectious disease specialist in 2002 and as clinical microbiologist in 2008, all at the University Medical Center Utrecht, the Netherlands. From 2008 till March 2021 he was head of the Department of Medical Microbiology. Since 2003 he is head of the research group of Infectious Disease Epidemiology of the Julius Center of Health Sciences and Primary Care and professor of molecular epidemiology of infectious diseases. He has been a principal investigator in many large scale epidemiologic studies and investigator-initiated randomized trials of prevention and treatment of infectious diseases. His experience covers the full range of epidemiologic study designs including clinical trials, cohorts, case-control studies and mathematical modelling to study antibiotic resistance and infection prevention. Specific research interests include the epidemiology of antibiotic-resistant bacteria such as VRE, MRSA and MDR Enterobacteriaceae, selective decontamination in intensive care unit patients, prevention of ventilator-associated pneumonia, treatment of community-acquired pneumonia, and prevention and treatment of community-acquired pneumonia, including COVID-19.

He is chairman of the strategic research program Infection & Immunity at the UMC Utrecht. (2017-)

Coordinator of the H2020-funded project ECRAID-Base (March 2021-) and Chief Executive Officer of the ECRAID foundation (Jan 2022-)

Member of the Koninklijke Nederlandse Academie voor Wetenschappen en Kunsten (Royal Academy of Sciences and Art) (April 2021-)

Research groups

Epidemiology and clinical trials in infectious diseases

Research aim

To improve prevention, diagnosis and treatment of infectious diseases and to establish an international research infrastructure for a rapid scientific response in the face of a new infectious disease threat.
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Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.
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Recent publications

Feasibility of tracking invasive Escherichia coli disease among older adults in a community setting Joachim Doua, Miquel Ekkelenkamp, Theo Verheij, Oscar Go, Stephen Ruhmel, Kimberly Leathers, Bart Spiessens, Sanne van Rooij, Vance G Fowler, Jeroen Geurtsen, Rowena Dolor, Michal Sarnecki, Ranee Chatterjee, Jan Poolman, Marc Bonten,
European Journal of Clinical Microbiology & Infectious Diseases, 2024, vol. 43, p.541-550
Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines—an exploratory sub-study of the BRACE trial Nicole Messina, Susie Germano, Rebecca McElroy, Rhian Bonnici, Branka Grubor-Bauk, David J. Lynn, Ellie McDonald, Suellen Nicholson, Kirsten Perrett, Laure Pittet, Rajeev Rudraraju, Natalie E. Stevens, Kanta Subbarao, Nigel Curtis, Andrew Davidson, Kaya Gardiner, Amanda Gwee, Tenaya Jamieson, Nicole Messina, Thilanka Morawakage, Susan Perlen, Kirsten Perrett, Laure Pittet, Amber Sastry, Jia Wei Teo, Francesca Orsini, Katherine Lee, Cecilia Moore, Suzanna Vidmar, Rashida Ali, Ross Dunn, Peta Edler, Grace Gell, Casey Goodall, Richard Hall, Ann Krastev, Nathan La, Nick McPhate, Thao Nguyen, Jack Ren, Luke Stevens, Ahmed Alamrousi, Thanh Dang, Jenny Hua, Marc Bonten, Axel Janssen, Cristina Prat-Aymerich, Darren Troeman, Nienke Paternotte, Bob Meek,
EBioMedicine, 2024, vol. 103, p.1-16
Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study Michiel van Boven, Christiaan H van Dorp, Ilse Westerhof, Vincent Jaddoe, Valerie Heuvelman, Liesbeth Duijts, Elandri Fourie, Judith Sluiter-Post, Marlies A van Houten, Paul Badoux, Sjoerd Euser, Bjorn Herpers, Dirk Eggink, Marieke de Hoog, Trisja Boom, Joanne Wildenbeest, Louis Bont, Ganna Rozhnova, Marc J Bonten, Mirjam E Kretzschmar, Patricia Bruijning-Verhagen
PLoS Computational Biology, 2024, vol. 20
Examining pancreatic stone protein response in ICU-acquired bloodstream infections Diede Verlaan, Lennie P G Derde, Tom van der Poll, Marc J M Bonten, Olaf L Cremer
Intensive Care Medicine Experimental, 2024, vol. 12
Universal Risk Factors for Mortality in Bloodstream Infections (UNIFORM) Ben Varon, Zaira R Palacios-Baena, Marlieke E A de Kraker, Jesús Rodríguez-Baño, Leonard Leibovici, Mical Paul, Marc Bonten, Yehuda Carmeli, Elena Carrara, Henry F Chambers, Joshua S Davis, George L Daikos, Marlieke de Kraker, Emanuele Durante-Mangoni, Angela Huttner, Andre C Kalil, Keith Kaye, Todd C Lee, Leonard Leibovici, Zaira R Palacios-Baena, David Paterson, Mical Paul, Pilar Retamar Gentil, Jesus Rodríiguez Baño, Luigia Scudeller, Evelina Tacconelli, Guy Thwaites, Steven Tong, Ben Varon, Dafna Yahav,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2024, vol. 30, p.453-461
Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE) Laure Pittet, Nicole Messina, Ellie McDonald, Francesca Orsini, Simone Barry, Marc Bonten, John Campbell, Julio Croda, Mariana G. Croda, Margareth Dalcolmo, Kaya Gardiner, Amanda Gwee, Bruno Jardim, Marcus V.G. Lacerda, Michaela Lucas, David J. Lynn, Laurens Manning, Kirsten Perrett, Jeffrey J. Post, Cristina Prat-Aymerich, Peter C. Richmond, Jorge L. Rocha, Jesus Rodriguez-Baño, Adilia Warris, Nicholas J. Wood, Andrew Davidson, Nigel Curtis, Tenaya Jamieson, Nicole Messina, Thilanka Morawakage, Susan Perlen, Kirsten Perrett, Laure Pittet, Amber Sastry, Jia Wei Teo, Katherine Lee, Cecilia Moore, Suzanna Vidmar, Rashida Ali, Ross Dunn, Peta Edler, Grace Gell, Casey Goodall, Richard Hall, Ann Krastev, Axel Janssen, Darren Troeman, Jan Kluytmans, Nienke Paternotte, Bob Meek,
EClinicalMedicine, 2024, vol. 72

Fellowships & Awards

2023: SWAB award 2023

2021: Tales of the unexpected in antimicrobial resistance

2018: Deutsche Gesellschaft fur Hygiene und Mikrobiologie: DGHM lecture 2018

2017: Honorary Fellowship of the RCPI

2015: ESCMID award for excellence in Clinical microbiology and Infectious Diseases 2015

2015: Promotor of the year, 2015

2006: Bacteriën met wiskunde te lijf