Profile photo Maarten Smits

Maarten Smits

Associate Professor - medical

Strategic program(s):

Biography

Maarten Smits is an associate professor, clinical scientist and interventional radiologist at UMC Utrecht, specializing in interventional oncology and minimally invasive, image-guided treatments for cancer patients. Appointed as Clinical Scientist in 2025, he has founded and leads the UMC Utrecht Interventional Oncology Research Team. Under his leadership, the team has expanded to 19 members, including PhD students and postdocs, and is participating in several EU-funded consortia.

His clinical and research focus lies in two domains: ablation and radioembolization. In ablation, he pioneered the Hepatic Arteriography and C-arm CT Guided Ablation (HepACAGA) technique for treating liver tumors. Since 2021, HepACAGA has become the standard method at UMC Utrecht, achieving significantly improved patient outcomes compared to conventional approaches. Its success has led to global adoption in more than 20 centers, with ongoing multicenter studies further validating its effectiveness.

In radioembolization, UMC Utrecht is internationally recognized for its groundbreaking work with holmium microspheres. Having contributed to pivotal studies such as HEPAR, SIM, and CAIRO7, Maarten now focuses on advancing tumor selectivity and simplifying treatment pathways.

His collaborations with industry partners—including Philips, Terumo, Medtronic, and Boston Scientific—have translated innovations from the lab into practice, ensuring access to cutting-edge treatments.

Beyond his research, Maarten plays a key role in medical education as Program Director for Interventional Radiology training at UMC Utrecht. He supervises PhD candidates, residents, and fellows, fostering a culture where collaboration, innovation, and learning from experience are central.

His academic contributions include more than 80 peer-reviewed publications, textbook chapters, and multiple international lectures at leading conferences such as CIRSE and ECIO. He serves on the editorial board of Cardiovascular and Interventional Radiology (CVIR) and contributes to national and international guideline development.

Through his leadership, research, and dedication to innovation, Maarten is helping shape the future of interventional oncology, with the vision of treating more patients effectively, sustainably, and with fewer resources—ultimately improving outcomes and quality of life for people living with cancer.

 

Grants and awards:

  • Horizon Europe IHI – PreciseOnco
  • Horizon Europe IHI – SHERPA
  • Horizon Europe IHI – IMAGIO
  • ZonMW Veelbelovende Zorg – CAIRO7
  • SKMS – Kwaliteitsnormen Interventieradiologie
  • KWF – Holmium radioembolization in HCC patients
  • Woldringprijs – Dutch Society for Nuclear Medicine
  • Fellowship Clinical Research Talent – UMC Utrecht
  • Alexander Suerman Stipendium – UMC Utrecht

Strategic program(s):

Contact

Research groups

Interventional oncology research group

Research aim

Interventional oncology is a fast-moving subspeciality providing image-guided treatment of cancer by interventional radiologists. Our aim is to help develop, evaluate and implement innovations in this field.

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Primary Liver Tumors research group

Research aim

To improve surveillance, diagnostics, treatment, and outcome for patients with primary liver tumors (hepatocellular carcinoma and cholangiocarcinoma) by interdisciplinary and (inter-)national collaborative research

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Recent publications

Nationwide strategies and outcomes of minimally invasive versus open combined liver ablation and resection for colorectal liver metastases Gabriela Pilz da Cunha, Ketharan Balasupramaniam, Niels Kok, Cornelis Verhoef, Paul D Gobardhan, Eric R Manusama, Maxime J L Dewulf, Christiaan van der Leij, Eric J T Belt, J Sven D Mieog, Mark C Burgmans, Wouter K G Leclercq, Marieke T de Boer, Simeon J S Ruiter, Gijs A Patijn, Maarten Vermaas, Jeroen Hagendoorn, Maarten L J Smits, Koop Bosscha, Steven J Oosterling, Hans Torrenga, Hendrik A Marsman, Esther C J Consten, Martijn R Meijerink, Rutger-Jan Swijnenburg,
European Journal of Surgical Oncology, 2026, vol. 52
Thermal Ablation of Hypervascular Liver Tumors After Selective Intra-Arterial Lipiodol Injection (SIALI) Kiyon Naser-Tavakolian, Abin Sajan, Alyssa Knight, Nikhil Jacob, Stephen P Reis, Ahmed Abdelal, Binta Patel, Michael A Clifton, Muhammad Usman Shahid, Kirema Garcia-Reyes, Leigh Casadaban, Maarten L J Smits, Zachary T Berman, Venkatesh P Krishnasamy
Cancers, 2026, vol. 18
Phase I Dose-Escalation Study Combining Irinotecan-Loaded Drug-Eluting Bead Chemoembolization with Yttrium-90 Glass Microspheres Radioembolization in Colorectal Liver Metastases (DEBIR90Y) Li Shen Ho, Ahmed Alsultan, Maarten L J Smits, Miriam Koopman, Rutger Bruijnen, Arthur J A T Braat, Kirk D Fowers, Matthew R Dreher, Guus M Bol, Marnix G E H Lam
Journal of Vascular and Interventional Radiology, 2026, vol. 37
A novel approach to radioembolization treatment planning using a hybrid [99mTc]Tc-MAA contrast enhanced SPECT/CT Grace Keane, Marnix G E H Lam, Maarten L J Smits, Guus M Bol, Hugo W A M de Jong, Rutger C G Bruijnen, Arthur J A T Braat
European Journal of Nuclear Medicine and Molecular Imaging, 2026, vol. 53, p.7038-7048
Radioembolization Practice in North America Versus Europe Grace Keane, Marnix G.E.H. Lam, Arthur J.A.T. Braat, Rutger C.G. Bruijnen, Nathalie Kaufmann, Hugo W.A.M. de Jong, Riad Salem, Maarten L.J. Smits
Current Oncology, 2026, vol. 33
Portal vein embolization versus radiation lobectomy as pre-treatment for major liver resection for colorectal liver metastases Khalil Ramdhani, Rosalie C M van Rees, Daan Andel, Jeanine M L Roodhart, Arthur J A T Braat, Rutger C G Bruijnen, Inne H M Borel Rinkes, Onno Kranenburg, Marnix G E H Lam, Maarten L J Smits, Jeroen Hagendoorn
Angiogenesis, 2026, vol. 29