Lodewijk Brosens

Associate Professor - medical

Strategic program(s):

Biography

2021-present: Clinical Scientist UMC Utrecht

2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.

2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore

2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam

2008-2013: Pathology residency

2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University

2006: M.D. University of Amsterdam

2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam

2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore

Strategic program(s):

Contact

lbrosens@umcutrecht.nl

Pure profile

Research groups

Pathology of gastrointestinal tract tumors

Research aim

Our aim is to increase understanding of the pathogenesis of gastrointestinal tract tumors and to identify and validate potential histopathological and molecular biomarkers to improve and personalize therapy for patients.

Go to group

Endocrine oncology research group

Research aim

To improve diagnostics, treatment and outcome for children and adults with Rare Endocrine Tumors by interdisciplinary and international collaborative research.

Go to group

Recent publications

All publications

Non-cell-autonomous mechanisms of tumor initiation and relapse by chromosomal instability Simona J A Lafirenze, Bastiaan van Gerwen, Ajit I Quirindongo, Natasja Costermans, Aniek Janssen, Banafsheh Etemad, Pim Toonen, Marco A D Louro, Wilma H M Hoevenaar, Sameh Youssef, Alain de Bruin, Lodewijk A A Brosens, Nannette Jelluma, Geert J P L Kops
Proceedings of the National Academy of Sciences of the United States of America, 2026, vol. 123

Intraductal Papillary Squamous Neoplasm (IPSN) of the Pancreas Michele Bevere, Antonio Pea, Volkan Adsay, Olca Basturk, Lodewijk A Brosens, Irene Esposito, Ralph H Hruban, David Klimstra, Seung-Mo Hong, Aatur D Singhi, Seung Soo Lee, Paola Mattiolo, Davide Pasini, Andrea Mafficini, Paola Piccoli, Serena Pedron, Calogero Ciulla, Antonietta Brighenti, Carlotta Franzina, Salvatore Paiella, Giuseppe Malleo, Roberto Salvia, Michele Milella, Riccardo De Robertis, Mirko D'Onofrio, Vincenzo Corbo, Rita T Lawlor, Aldo Scarpa, Claudio Luchini
Modern Pathology, 2026, vol. 39

Mapping the genetic landscape of hereditary diffuse-type gastric cancer progression Lars J S Kemp, Remco van Cruchten, Robin Lomans, Natasja Rutgers, Lodewijk A A Brosens, Liudmila L Kodach, Jolanda M van Dieren, Tanya M Bisseling, Richarda de Voer, Martijn Gloerich, Chella R S van der Post
Gastric Cancer, 2026, vol. 29, p.527-539

Detecting aberrant p53 immunohistochemical expression patterns in patients with Barrett’s esophagus using artificial intelligence Michel Botros, Luuk Verheijen, Onno J. de Boer, Hans Halfwerk, Lodewijk A.A. Brosens, Fiebo J.C. ten Kate, Ariadne H.A.G. Ooms, Lindsey Oudijk, Chella R.S. van der Post, Myrtle J. van der Wel, Erik J. Bekkers, Hoel Kervadec, Clara I. Sánchez, Sybren L. Meijer
Journal of Medical Imaging, 2026, vol. 13

WNT7B drives a program for pancreatic cancer subtype switching and progression Joep Sprangers, Jeroen M. Bugter, Despina Xanthakis, Michiel Boekhout, Rutger N.U. Kok, Veerle E. Geurts, Hans Clevers, Lodewijk A.A. Brosens, Frederike Dijk, Maria J. Rodríguez Colman, Jelte Y. van der Vaart, Madelon M. Maurice
iScience, 2026, vol. 29

Pancreatic cancer risk and survival in patients with Lynch syndrome Aleksander M Bogdanski, Derk C F Klatte, Bert A Bonsing, Lodewijk A A Brosens, Evelien Dekker, Lydia G van der Geest, Joep E G Ijspeert, Jan J Koornstra, Mariëtte C A van Kouwen, Alexandra M J Langers, Maartje Nielsen, Dewkoemar Ramsoekh, Manon C Spaander, Wouter H de Vos Tot Nederveen Cappel, Jeanin E Van Hooft, Monique E van Leerdam,
EClinicalMedicine, 2026, vol. 91

Fellowships & Awards

2018: University of Verona Internationalization Program Stipend

2014: MLDS Career Development Grant

2013: UICC Yamagiwa-Yoshida Memorial international study grant

2013: Nijbakker-Morra Stichting Stipend

External positions

Lid, patholoog - Landelijke revisie van Barrett slokdarm biopten - Landelijk Adviesorgaan Neoplasie Slokdarm (LANS)

Patholoog - Gastrointestinal and pancreato-biliary pathology - Radboudumc