Profile photo Lennie Derde

Lennie Derde

Assistant Professor - medical

Strategic program(s):


Lennie is an ICU consultant with a background in infectious diseases and epidemiology. She co-leads (with Olaf Cremer) the "epidemiology of sepsis and inflammation" research group at the Intensive Care Center of the UMCU, supervising 8 PhDs and 2 postdoctoral researchers. Her research focuses on clinical trials in critically ill patients, especially those with sepsis and severe infections. Lennie is the European lead and immediate past chair of the global TSC of REMAP-CAP, and a co-applicant and work package leader on EU-funded projects like RECOVER and ECRAID-Base. Lennie leads the ZonMw funded IMPRINT consortium and is co-applicant on several international collaborative grants. She is a member of several DSMBs, guideline committees and advisory committees (all unpayed), and a member of the ESICM executive committee as the Education and Training Committee lead.

Research groups

Epidemiology and clinical trials in infectious diseases

Research aim

To improve prevention, diagnosis and treatment of infectious diseases and to establish an international research infrastructure for a rapid scientific response in the face of a new infectious disease threat.
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Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.
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Recent publications

The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients M A Slim, E H T Lim, L A van Vught, A M Tuip-de Boer, E Rademaker, J L G Haitsma Mulier, J J Engel, P Pickkers, F L van de Veerdonk, A P J Vlaar, L P G Derde, N P Juffermans,
Scientific Reports, 2024, vol. 14
Examining pancreatic stone protein response in ICU-acquired bloodstream infections Diede Verlaan, Lennie P G Derde, Tom van der Poll, Marc J M Bonten, Olaf L Cremer
Intensive Care Medicine Experimental, 2024, vol. 12
Reframing sepsis immunobiology for translation Manu Shankar-Hari, Thierry Calandra, Miguel P Soares, Michael Bauer, W Joost Wiersinga, Hallie C Prescott, Julian C Knight, Kenneth J Baillie, Lieuwe D J Bos, Lennie P G Derde, Simon Finfer, Richard S Hotchkiss, John Marshall, Peter J M Openshaw, Christopher W Seymour, Fabienne Venet, Jean-Louis Vincent, Christophe Le Tourneau, Anke H Maitland-van der Zee, Iain B McInnes, Tom van der Poll
The Lancet Respiratory Medicine, 2024, vol. 12, p.323-336
Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients Madelief Bolscher, Stephanie C.E. Koster, Matty Koopmans, Jelle L.G. Haitsma Mulier, Lennie P.G. Derde, Nicole P. Juffermans
Critical care (London, England), 2024, vol. 28
Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case-control study Meri R J Varkila, Diana M Verboom, Lennie P G Derde, Tom van der Poll, Marc J M Bonten, Olaf L Cremer,
Annals of Intensive Care, 2024, vol. 14
Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19 Lucas C. Godoy, Matthew D. Neal, Ewan C. Goligher, Mary Cushman, Brett L. Houston, Charlotte A. Bradbury, Zoe K. McQuilten, Tobias Tritschler, Susan R. Kahn, Lindsay R. Berry, Elizabeth Lorenzi, Tom Jensen, Alisa M. Higgins, Lucy Z. Kornblith, Jeffrey S. Berger, Michelle N. Gong, Jonathan D. Paul, Lana A. Castellucci, Grégoire Le Gal, Sylvain A. Lother, Robert S. Rosenson, Lennie P.G. Derde, Anand Kumar, Bryan J. McVerry, Jose C. Nicolau, Eric Leifer, Jorge Escobedo, David T. Huang, Harmony R. Reynolds, Marc Carrier, Keri S. Kim, Beverley J. Hunt, Arthur S. Slutsky, Alexis F. Turgeon, Steven A. Webb, Colin J. McArthur, Michael E. Farkouh, Judith S. Hochman, Ryan Zarychanski, Patrick R. Lawler
JACC: Advances, 2024, vol. 3, p.100780