Profile photo Dennis Klomp

Dennis Klomp

Full Professor

Biography

Research interests

In my research team, we are investigating novel methods to enable imaging of metabolism and physiology of diseases and treatments non-invasively to aid clinical decision making. Using ultra-high magnetic fields, we demonstrated feasibility of imaging metabolism with magnetic resonance in the human body at clinically relevant spatial resolutions. Observing physiology and metabolism will provide a more direct and therefore faster and accurate means to characterize diseases and responses to treatments when compared to conventional morphologic imaging as known from cell studies. In fact, we have recently proven that metabolic images can predict efficacy of neoadjuvant chemotherapy in breast cancer much better and faster than any morphologic imaging technique could. The results have motivated public-private partnerships in translating the technology for clinical studies involving metabolic MRI throughout the body.

Compared to a few morpholic imaging contrasts conventionally available in radiology, potentially hundred of different metabolite levels could soon be imaged. Our innovation therefore brings radiology into the world of biochemistry and visa versa, creating a new bridge between research groups in identifying what non-invasively detectable metabolites would be useful for aiding clinic. In parallel, acceleration techniques in imaging are being investigated to maximize metabolic and physiologic information within a single scan session for each patient. These incorporate high density receiver array and even novel ways in gradient coil designs that speed up (metabolic) MRI with an anticiptated acceleration of an order of magnitude.

The very first prototype worldwide of metabolic MRI dedicated for clinical use will become available at the UMCU and clinical projects are being compiled for the focus areas of cancer, heart/vasculature, regenerative medicine, child, infections, brain. Teams from Dutch UMCU’s will use our system, while plans have been compiled to take the scientific lead of the next 8 systems positioned worldwide (3 already confirmed) prior to FDA approval.

Research groups

High field MRI research group

Research aim

Our research lines incorporate inventions of MR technology to be able to see the unseen for advancing medicine. Our clinical research focus areas are cancer, dementia, cardiovascular, stroke and MSK.

Go to group

Recent publications

Measurement of metabolite levels and treatment-induced changes in hepatic metastases of gastro-esophageal cancer using 7-T phosphorus magnetic resonance spectroscopic imaging Lieke van den Wildenberg, Bobby A Runderkamp, Leonard W F Seelen, Hanneke W M van Laarhoven, Mark W J M Gosselink, Wybe J M van der Kemp, Nadia Haj Mohammad, Dennis W J Klomp, Jeanine J Prompers
NMR in Biomedicine, 2024, vol. 37
A silent echo-planar spectroscopic imaging readout with high spectral bandwidth MRSI using an ultrasonic gradient axis Edwin Versteeg, Kyung Min Nam, Dennis W.J. Klomp, Alex A. Bhogal, Jeroen C.W. Siero, Jannie P. Wijnen
Magnetic Resonance in Medicine, 2024, vol. 91, p.2247-2256
Amide proton transfer weighted imaging in pediatric neuro-oncology Iris V. Obdeijn, Evita C. Wiegers, Lejla Alic, Sabine L.A. Plasschaert, Mariëtte E.G. Kranendonk, Hans M. Hoogduin, Dennis W.J. Klomp, Jannie P. Wijnen, Maarten H. Lequin
NMR in Biomedicine, 2024, vol. 37
Indirect 1H-[ 13C] MRS of the human brain at 7 T using a 13C-birdcage coil and eight transmit-receive 1H-dipole antennas with a 32-channel 1H-receive array. Sarah M Jacobs, Jeanine J Prompers, Wybe J M van der Kemp, Tijl A van der Velden, Mark Gosselink, Ettore Flavio Meliadò, Hans M Hoogduin, Graeme F Mason, Robin A de Graaf, Corin O Miller, Gerard M Bredael, Anja G van der Kolk, Cezar Alborahal, Dennis W J Klomp, Evita C Wiegers
NMR in Biomedicine, 2024, vol. 37
Fast and silent MRI using nonlinear gradient fields at the ultrasonic gradient switching frequency of 20 kHz with a Point Spread Function framework reconstruction Michael J B McGrory, Edwin Versteeg, Alessandro Sbrizzi, Cornelis A T van den Berg, Dennis Klomp, Jeroen C W Siero
Magnetic Resonance in Medicine, 2024, vol. 92, p.2734-2748
Deuterium body array for the simultaneous measurement of hepatic and renal glucose metabolism and gastric emptying with dynamic 3D deuterium metabolic imaging at 7T Ayhan Gursan, Arjan D Hendriks, Dimitri Welting, Pim A de Jong, Dennis W J Klomp, Jeanine J Prompers
NMR in Biomedicine, 2023, vol. 36, p.1-14

External positions

Non executive board member (no shares) - Advisor MRI technology - Tesla Engineering