Kevin Kenna

Associate Professor

Strategic program(s):

Contact

k.p.kenna@umcutrecht.nl

Pure profile

Research groups

Neurogenetics

Research aim

Given increasing possibilities in gene-based therapies for ALS, the overall aim of my research is to elucidate the exact genetic contribution in every patient to liability to disease.

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Recent publications

All publications

Small RNA sequencing identifies serum tDR-1:34-Gly-GCC tiRNA levels as a biomarker for survival in amyotrophic lateral sclerosis Koen C. Demaegd, Lindy Kool, Sharada Baindoor, Paul D. Donovan, Junyi Su, Henk Jan Westeneng, Ruben P.A. van Eijk, Grainne Geoghegan, Elena Perez Morrissey, Luise Halang, Koen Poesen, Pegah Masrori, Hesham A.Y. Gibriel, Elisabeth Jirström, Morten T. Venø, Jørgen Kjems, Orla Hardiman, Jan H. Veldink, Kevin Kenna, Leonard H. van den Berg, Philip Van Damme, Jochen H.M. Prehn, Michael A. van Es
iScience, 2026, vol. 29

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis Paul J. Hop, Maarten Kooyman, Brendan J. Kenna, Ramona A.J. Zwamborn, Kristel R. van Eijk, Yan Wang, Charlotte H. van Dijk, Erwin Bekema, Wouter van Rheenen, Paul Beele, Joke J.F.A. van Vugt, Mamede de Carvalho, Leonard H. van den Berg, Philip Van Damme, Bradley N. Smith, Ahmad Al Khleifat, Alfredo Iacoangeli, Johnathan Cooper-Knock, Bradley N. Smith, Simon Topp, Anneke J. van der Kooi, Vera Fominykh, Vivian Drory, Yossef Lerner, Yehuda Shovman, Dominic B. Rowe, Kelly L. Williams, Russell L. McLaughlin, Jessica Hurt, Yunfeng Huang, Chia Yen Chen, Ellen Tsai, Heiko Runz, Eleonora Aronica, Ewout J.N. Groen, Michael A. van Es, R. Jeroen Pasterkamp, Sali M.K. Farhan, Fleur C. Garton, Allan F. McRae, Pamela A. McCombe, Robert D. Henderson, Dongsheng Fan, Lenka Šlachtová, Helle Høyer, Agnes L. Nishimura, Philip Van Damme, Leonard H. van den Berg, Kevin P. Kenna, Jan H. Veldink, , , ,
Nature genetics, 2026, vol. 58, p.717-725

Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS Sai Zhang, Tobias Moll, Jasper Rubin-Sigler, Sharon Tu, Shuya Li, Enming Yuan, Menghui Liu, Marriane King, Elham Alhathli, Connie Treanor, Alison Twelvetrees, Marcel Weinreich, Sam Bonsall, Calum Harvey, Sarah Gornall, Allan Shaw, Johanna Ganssauge, Akshay Bhinge, Cleide Dos Santos Souza, Laura Ferraiuolo, Eran Hornstein, Ophir Shalem, Anna Avila, Tatyana Shelkovnikova, Charlotte H van Dijk, Ilia S Timpanaro, Kevin P Kenna, Jianyang Zeng, Philip van Damme, Philip S Tsao, Pamela J Shaw, Justin K Ichida, Johnathan Cooper-Knock, Michael P Snyder
2025

Optimised machine learning for time-to-event prediction in healthcare applied to timing of gastrostomy in ALS Marcel Weinreich, Harry McDonough, Mark Heverin, Éanna Mac Domhnaill, Nancy Yacovzada, Iddo Magen, Yahel Cohen, Calum Harvey, Ahmed Elazzab, Sarah Gornall, Sarah Boddy, James J.P. Alix, Julian M. Kurz, Kevin P. Kenna, Sai Zhang, Alfredo Iacoangeli, Ahmad Al-Khleifat, Michael P. Snyder, Esther Hobson, Adriano Chio, Andrea Malaspina, Andreas Hermann, Caroline Ingre, Juan Vazquez Costa, Leonard van den Berg, Monica Povedano Panadés, Philip van Damme, Phillipe Corcia, Mamede de Carvalho, Ammar Al-Chalabi, Eran Hornstein, Eran Elhaik, Pamela J. Shaw, Orla Hardiman, Christopher McDermott, Johnathan Cooper-Knock
EBioMedicine, 2025, vol. 121

SpliPath enhances disease gene discovery in case-control analyses of rare splice-altering genetic variants Yan Wang, Charlotte van Dijk, Ilia Timpanaro, Paul Hop, Brendan Kenna, Maarten Kooyman, Eleonora Aronica, R. Jeroen Pasterkamp, Leonard H. van den Berg, Johnathan Cooper-Knock, Jan H. Veldink, Kevin Kenna, ,
Cell reports methods, 2025, vol. 5, p.1-12

Correction to Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Michael P. Snyder, Alexander Schönhuth, Letitia M.F. Sng, Natalie A. Twine,
Genome Biology, 2025, vol. 26