Profile photo Jo Höppener

Jo Höppener

Associate Professor

Strategic program(s):


Jo Höppener graduated (cum laude) in 1981 in Biology at Utrecht University. He did his Ph.D. (cum laude) in 1988 with Prof. Lips and Prof. Jansz (financed by NWO and Ciba Geigy). Part of the Ph.D. study was performed at the Johns Hopkins Hospital (Baltimore, USA). He was research fellow at Utrecht University until 1989 (financed by STW), when he was awarded a 5-year fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW). He was appointed senior research scientist in the Faculty of Medicine (presently UMC Utrecht) at the Division of Internal Medicine in 1994. He was appointed Associate Professor at the Division of Biomedical Genetics at UMC Utrecht in 2005 and his research was incorporated in the Laboratory of Translational Immunology in 2013. The major research theme of his group is the role of IAPP and islet amyloid in islet ß-cell dysfunction in Type 2 diabetes mellitus (DM2). To this end they have generated a transgenic mouse model, in which the amyloidogenic human IAPP is expressed in the islet ß-cells. This unique animal model is used for pioneering research on the pathogenesis, diagnosis and therapy of DM2.

Strategic program(s):


Recent publications

Human IAPP is a contributor to painful diabetic peripheral neuropathy Mohammed Mh Albariqi, Sabine Versteeg, Elisabeth M Brakkee, J Henk Coert, Barend Ow Elenbaas, Judith Prado, C Erik Hack, Jo Wm Höppener, Niels Eijkelkamp
Journal of Clinical Investigation, 2023, vol. 133
Variable clinical expression in patients with a germline MEN1 disease gene mutation: clues to a genotype-phenotype correlation. C.J.M. Lips, K.M.A. Dreijerink, J.W.M. Hoppener
Clinics (São Paulo, Brazil), 2012, vol. 67, p.49-56
Ethics: Genetic testing for MEN1-whose responsibility? C.J.M. Lips, J.W.M. Höppener
Nature Reviews. Endocrinology, 2012, vol. 8, p.575-576
The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition L.P. Khemtemourian, M.F.M. Engel, R.M.J. Liskamp, J.W.M. Höppener, J.A. Killian
Biochimica et Biophysica Acta-Biomembranes, 2010, vol. 1798, p.1805-1811
The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes L.P. Khemtemourian, M.F.M. Engel, J.A.W. Kruijtzer, J.W.M. Hoppener, R.M.J. Liskamp, J.A. Killian
European Biophysics Journal, 2010, vol. 39, p.1359-1364
P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development W. van Veelen, R. Klompmaker, M. Gloerich, C.J.R. van Gasteren, E. Kalkhoven, R. Berger, C.J.M. Lips, R.H. Medema, J.W.M. Höppener, D.S. Acton
International Journal of Cancer, 2009, vol. 124, p.339-345