Profile photo Jeanette Leusen

Jeanette Leusen

Full Professor

Strategic program(s):

Biography

Prof. Jeanette Leusen, received her PhD in 1995 at the University of Amsterdam, The Netherlands. She became associate professor and head of the immunotherapy group of the University Medical Center in Utrecht in 2006, and head of the UMAB facility in 2012. She has co-authored more than 150 publications in peer-reviewed journals and is inventor on 13 patent applications. Her group of 24 FTE works on the mechanism of action of therapeutic antibodies, with a special interest in IgA as a novel class of antibody for the treatment of both malignant as infectious disease.

Research groups

Pediatric immunology team

Research aim

The pediatric immunology team focuses on the under-explored research field of immune response modification for the prevention of immune-driven diseases. The goal of our research is to develop interventions that can prevent disease manifestations.

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Antibody therapy

Research aim

In our research, we aim to understand antibodies in all aspects, from fundamental research to therapeutic applications including their mode of action, e.g. Fc receptors and complement, for cancer, auto immunity and infectious diseases.

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Recent publications

Myeloid cell–mediated killing of B-ALL by CD38 and CD20 IgA antibody variants is enhanced by CD47/SIRPα interference Marta Lustig, Maja Kowol, Alina M. Hartmann, Ida C. van der Peet, Marco J.H. Jansen, Katharina Iben, Dorothee Winterberg, Steffen Krohn, Niklas Baumann, Thies Rösner, Sonja Bendig, Christoph Hahn, Alexander A. Wurm, Carina L. Gehlert, Miriam Denker, Pipob Suwanchaikasem, Arturo Macarrón Palacios, Stefan Schwartz, Monika Brüggemann, Renate Burger, Kerstin Schmitt, Katja Klausz, Oliver Valerius, Friedrich Stölzel, Lorenz Bastian, Claudia D. Baldus, Matthias Peipp, Jeanette H.W. Leusen, Denis M. Schewe, Thomas Valerius
Blood Neoplasia, 2026, vol. 3
IgM Anti-Ganglioside Binding and Complement Activation in an iPSC-Derived Motor Neuron Model for Multifocal Motor Neuropathy Daniëlle Krijgsman, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M. Bloemenkamp, Jeroen W. Bos, Ruben P.A. van Eijk, Inge Van de Walle, Ruth Huizinga, Bart C. Jacobs, Jeanette H.W. Leusen, R. Jeroen Pasterkamp, C. Erik Hack, Kevin Budding, W. Ludo van der Pol
Neurology(R) neuroimmunology & neuroinflammation, 2026, vol. 13
Quantification of Signal Transduction Pathway Activity in Pancreatic Ductal Adenocarcinoma Léon Raymakers, Lois A Daamen, Martijn P W Intven, Jeanette H W Leusen, Patricia A Olofsen, Anja van de Stolpe, Reinier A P Raymakers
International Journal of Molecular Sciences, 2025, vol. 26
Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses Tosca Holtrop, Arianne M Brandsma, Louris J Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M Passchier, Maaike Nederend, J H Marco Jansen, Anouk G van Mourik, Rolf T Urbanus, Diane van der Woude, Roger E G Schutgens, Rene E M Toes, Bert J C Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H W Leusen
Nature Communications, 2025, vol. 16
Extracellular domain 1 of human FcγRI (CD64) identified as the binding site for anti-FcγRI antibodies Tosca Holtrop, Elsemieke M Passchier, Sophie O'Toole, W Joost Kraan, Kevin Budding, Jeanette H W Leusen
mAbs, 2025, vol. 17
High-plex imaging of hepatoblastoma and adjacent liver in pediatric patients reveals a predominant myeloid infiltrate expressing immune-checkpoints Daniëlle Krijgsman, Stephanie A Schubert, Lianne J Kraaier, Yuyan Lu, Kristof van Avondt, Meggy E L Verdonschot, Jeanette H W Leusen, Marius C van den Heuvel, Ruben H de Kleine, Vincent E de Meijer, Kathelijne C J Kraal, Ronald R de Krijger, József Zsiros, Weng Chuan Peng, Yvonne Vercoulen
Cancer Immunology, Immunotherapy, 2025, vol. 74

Fellowships & Awards

Dr Leusen holds several grants from Health Holland, KWF, Villa Joep! and industry.