Martijn Gloerich

Associate Professor

Strategic program(s):

Contact

mgloeric@umcutrecht.nl

Pure profile

Research groups

Mechanobiology of epithelial homeostasis and cancer

Research aim

Our aim is to elucidate how cells respond to mechanical forces to control healthy epithelial homeostasis, and to understand how alterations in force-dependent communication contribute to tumor development.

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Recent publications

All publications

Cyclin-dependent kinase CDK1 targets cell-cell junction components and governs epithelial monolayer integrity throughout the cell cycle Margarida Dantas, Lisa Donker, Willem-Jan Pannekoek, Marjolein J Vliem, Jan A van der Beek, Robert M van Es, Harmjan R Vos, Judith Klumperman, Martijn Gloerich
Science Signaling, 2026, vol. 19

Mapping the genetic landscape of hereditary diffuse-type gastric cancer progression Lars J S Kemp, Remco van Cruchten, Robin Lomans, Natasja Rutgers, Lodewijk A A Brosens, Liudmila L Kodach, Jolanda M van Dieren, Tanya M Bisseling, Richarda de Voer, Martijn Gloerich, Chella R S van der Post
Gastric Cancer, 2026, vol. 29, p.527-539

β-catenin condensation facilitates clustering of the cadherin/catenin complex and formation of nascent cell-cell junctions Jooske L Monster, Caterina Manzato, Jan A van der Beek, Willem-Jan Pannekoek, Janneke A Hummelink, Michael A Hadders, Cecilia de Heus, Judith Klumperman, Jurian Schuijers, Martijn Gloerich
Nature Communications, 2025, vol. 17

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state Mirjam C van der Net, Marjolein J Vliem, Lars J S Kemp, Carlos Perez-Gonzalez, Tariq S Haddad, Esther A Strating, Ana Krotenberg-Garcia, Ronja M Houtekamer, Willem-Jan Pannekoek, Karen B van den Anker, Susan Zwakenberg, Jooske L Monster, Suzanne E M van der Horst, Hugo J G Snippert, Antoine A Khalil, Jacco van Rheenen, Saskia J E Suijkerbuijk, Onno Kranenburg, Femke Simmer, Iris D Nagtegaal, Danijela Matic Vignjevic, Martijn Gloerich
Cell Reports, 2025, vol. 44

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients Julian R Buissant des Amorie, Max A Betjes, Jochem H Bernink, Joris H Hageman, Veerle E Geurts, Harry Begthel, Dimitrios Laskaris, Maria C Heinz, Ingrid Jordens, Tiba Vinck, Ronja M Houtekamer, Ingrid Verlaan-Klink, Sascha R Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J Tans, Jeroen S van Zon, Hugo J G Snippert
Nature Communications, 2025, vol. 16

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding Ronja M Houtekamer, Mirjam C van der Net, Marjolein J Vliem, Tomas E J C Noordzij, Lisa van Uden, Robert M van Es, Joo Yong Sim, Eriko Deguchi, Kenta Terai, Matthew A Hopcroft, Harmjan R Vos, Beth L Pruitt, Michiyuki Matsuda, Willem-Jan Pannekoek, Martijn Gloerich
Science Signaling [E], 2025, vol. 18