Profile photo Floris Lafeber

Floris Lafeber

Full Professor

Biography

Floris Lafeber (1961) is professor of ‘Experimental Rheumatology’ at the UMC Utrecht. He studied Biology at the University of Nijmegen (NL; graduated Nov 1984) and did his PhD at this University in collaboration with the Univerity of Leiden (NL), with a visit of three months at the department of Physiology, Univ. of Ottawa (Canada) (graduated April 1988).  He is scientifically active in the field of ‘Regenerative Medicine’ and ‘Immunology’.

Currently, his main research interest is in 1) Implementation of joint distraction in the treatment of knee osteoarthritis; 2) The potential of IL4-10 synerkine in control of cartilage damage, inflammation, and pain in osteoarthritis (and haemophilic arthropathy); 3) The prediction of progression and response to treatment in osteoarthritis, rheumatoid arthritis, and haemophilic arthropathy.

Floris Lafeber is (co-)author of over 300 peer-reviewed papers (H-index 48), of which more than half in the top 10% of the field. He co-supervised 30 PhD students with several additionally scheduled. He has several patent (provisional) in the fields described above, and gained over his career for more than 15 million Euros research funding from the Dutch Arthritis Association, government, and industry. At present he is manager of research and head of research laboratory of the department of Rheumatology & Clinical Immunology, UMCU (3 days/week)

Recent publications

Dextran-tryamine hydrogel maintains position and integrity under simulated loading in a human cadaver knee model G. S. van der Weiden, S. C. Mastbergen, S. K. Both, M. Karperien, F. P. Lafeber, N. van Egmond, R. J.H. Custers
Osteoarthritis and Cartilage Open, 2024, vol. 6
The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period M. Teunissen, B. P. Meij, L. Snel, K. Coeleveld, J. Popov-Celeketic, I. S. Ludwig, F. Broere, F. P.J.G. Lafeber, M. A. Tryfonidou, S. C. Mastbergen
Journal of Orthopaedic Translation, 2023, vol. 38, p.44-55
Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort Mylène P. Jansen, Wolfgang Wirth, Jaume Bacardit, Eefje M. van Helvoort, Anne C.A. Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Cristoph H. Ladel, Marieke Loef, Floris P.J.G. Lafeber, Paco M. Welsing, Simon C. Mastbergen, Frank W. Roemer
Quantitative Imaging in Medicine and Surgery, 2023, vol. 13, p.3298-3306
Structural changes after ankle joint distraction in haemophilic arthropathy Eline D P van Bergen, Simon C Mastbergen, Floris P J G Lafeber, Anne-Christine Bay-Jensen, Sofie F Madsen, Helena Port, Wouter Foppen, Roger E G Schutgens, Mylène P Jansen, Lize F D van Vulpen
Haemophilia, 2023, vol. 29, p.874-882
Subclinical synovial proliferation in patients with severe haemophilia A Eline D.P. van Bergen, Flora H.P. van Leeuwen, Wouter Foppen, Merel A. Timmer, Roger E.G. Schutgens, Simon C. Mastbergen, Floris P.J.G. Lafeber, Pim A. de Jong, Kathelijn Fischer, Lize F.D. van Vulpen
Haemophilia, 2023, vol. 29, p.1580-1588
Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort Sara Altamirano, Mylène P. Jansen, Daniel L. Oberski, Marinus J.C. Eijkemans, Simon C. Mastbergen, Floris P.J.G. Lafeber, Willem E. van Spil, Paco M.J. Welsing
PLoS ONE, 2023, vol. 18