Ewout Groen

Associate Professor

Strategic program(s):

Contact

egroen3@umcutrecht.nl

Pure profile

Research groups

Research in Spinal Muscular Atrophy

Research aim

The Netherlands SMA Center is the single dedicated center for SMA in the Netherlands, including newborn screening, diagnostics, care, treatments and scientific research. We conduct various national and internal clinical trials and studies.

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Recent publications

All publications

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis Paul J. Hop, Maarten Kooyman, Brendan J. Kenna, Ramona A.J. Zwamborn, Kristel R. van Eijk, Yan Wang, Charlotte H. van Dijk, Erwin Bekema, Wouter van Rheenen, Paul Beele, Joke J.F.A. van Vugt, Mamede de Carvalho, Leonard H. van den Berg, Philip Van Damme, Bradley N. Smith, Ahmad Al Khleifat, Alfredo Iacoangeli, Johnathan Cooper-Knock, Bradley N. Smith, Simon Topp, Anneke J. van der Kooi, Vera Fominykh, Vivian Drory, Yossef Lerner, Yehuda Shovman, Dominic B. Rowe, Kelly L. Williams, Russell L. McLaughlin, Jessica Hurt, Yunfeng Huang, Chia Yen Chen, Ellen Tsai, Heiko Runz, Eleonora Aronica, Ewout J.N. Groen, Michael A. van Es, R. Jeroen Pasterkamp, Sali M.K. Farhan, Fleur C. Garton, Allan F. McRae, Pamela A. McCombe, Robert D. Henderson, Dongsheng Fan, Lenka Šlachtová, Helle Høyer, Agnes L. Nishimura, Philip Van Damme, Leonard H. van den Berg, Kevin P. Kenna, Jan H. Veldink, , , ,
Nature genetics, 2026, vol. 58, p.717-725

Prenatal SMN-dependent defects in translation uncover reversible primary cilia phenotypes in spinal muscular atrophy Federica Genovese, Yu Ting Huang, Anna Al Motyl, Martina Paganin, Gaurav Sharma, Ilaria Signoria, Deborah Donzel, Nicole Ch Lai, Marie Pronot, Rachel A. Kline, Helena Chaytow, Kimberley J. Morris, Kiterie Me Faller, Thomas M. Wishart, Ewout Jn Groen, Michael A. Cousin, Gabriella Viero, Thomas H. Gillingwater
JCI Insight, 2025, vol. 10

Safety through design Ewout J.N. Groen, Renske I. Wadman
Molecular Therapy Methods and Clinical Development, 2025, vol. 33

Further Comments on Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy Renske I Wadman, Ewout J N Groen, W Ludo van der Pol
The New England journal of medicine, 2025, vol. 393

Comprehensive analysis across SMN2 excludes DNA methylation as an epigenetic biomarker for spinal muscular atrophy Maria M. Zwartkruis, Joris V. Kortooms, Demi Gommers, Martin G. Elferink, Ilaria Signoria, Joyce van der Sel, Paul J. Hop, Ramona A.J. Zwamborn, Robin Geene, Jared W. Green, Hanneke W.M. van Deutekom, Wouter van Rheenen, Jan H. Veldink, Fay Lynn Asselman, Renske I. Wadman, W. Ludo van der Pol, Gijs W. van Haaften, Ewout J.N. Groen
iScience, 2025, vol. 28

Dynamic modulation of the motor neuron translatome during developmental synapse elimination Dinja van der Hoorn, Fabio Lauria, Helena Chaytow, Kiterie M E Faller, Yu-Ting Huang, Rachel A Kline, Ilaria Signoria, Kim Morris, Thomas M Wishart, Ewout J N Groen, Gabriella Viero, Thomas H Gillingwater
Science Signaling [E], 2025, vol. 18