Profile photo Dylan de Lange

Dylan de Lange

Full Professor

Strategic program(s):

Biography

Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center (nvic.umcutrecht.nl). As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 240,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the all Dutch ICUs. Part of his current research is derived from this large national registry: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

In 2019 a large European research project started looking at the (long-term) outcomes of intoxicated patients on various ICUs in the World. Can we predict outcome based on variables that ate present at admission to the hospital? This INTOXICATE study is now closed and the first analyses are being published.

Recent publications

Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU) Matteo Bassetti, Daniele R Giacobbe, Christina Agvald-Ohman, Murat Akova, Ana Alastruey-Izquierdo, Sevtap Arikan-Akdagli, Elie Azoulay, Stijn Blot, Oliver A Cornely, Manuel Cuenca-Estrella, Dylan W de Lange, Francesco G De Rosa, Jan J De Waele, George Dimopoulos, Jose Garnacho-Montero, Martin Hoenigl, Souha S Kanj, Philipp Koehler, Bart J Kullberg, Frédéric Lamoth, Cornelia Lass-Flörl, Johan Maertens, Ignacio Martin-Loeches, Patricia Muñoz, Garyphallia Poulakou, Jordi Rello, Maurizio Sanguinetti, Fabio S Taccone, Jean-François Timsit, Antoni Torres, Jose A Vazquez, Joost Wauters, Erika Asperges, Andrea Cortegiani, Cecilia Grecchi, Ilias Karaiskos, Clément Le Bihan, Toine Mercier, Klaus L Mortensen, Maddalena Peghin, Chiara Rebuffi, Sofia Tejada, Antonio Vena, Valentina Zuccaro, Luigia Scudeller, Thierry Calandra,
Intensive Care Medicine, 2024, vol. 50, p.502-515
Application of European Society of Cardiology guidelines for evaluating acute coronary syndrome risk in low-risk patients with cocaine-associated chest pain F. M.J. Gresnigt, L. K. Heikamp, J. J.W. van Essen, L. F.J. Walraven, C. E.E. van Ofwegen-Hanekamp, S. Mollink, E. J.F. Franssen, D. W. de Lange, R. K. Riezebos
Toxicology Reports, 2024, vol. 13, p.1-6
Predicting the outcome in poisoned patients Samanta M Zwaag, Claudine C Hunault, Dylan W de Lange
Clinical Toxicology , 2024, vol. 62, p.139-144
The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring Tinka Bakker, Joanna E Klopotowska, Dave A Dongelmans, Saeid Eslami, Wytze J Vermeijden, Stefaan Hendriks, Julia Ten Cate, Attila Karakus, Ilse M Purmer, Sjoerd H W van Bree, Peter E Spronk, Martijn Hoeksema, Evert de Jonge, Nicolette F de Keizer, Ameen Abu-Hanna, , Dylan deLange
Lancet (London, England), 2024, vol. 403, p.439-449
Cardiotoxicity After Synthetic Cathinone Use K L Groenewegen, F M J Gresnigt, J J Nugteren-van Lonkhuyzen, C den Haan, E J F Franssen, R K Riezebos, D Ohana, D W de Lange
Cardiovascular Toxicology, 2024, vol. 24, p.209-224
Risk factors for deliberate self-poisoning among children and adolescents in The Netherlands Ilze M J Thoonen, Saskia J Rietjens, Agnes G van Velzen, Dylan W de Lange, Arjen Koppen
Clinical Toxicology , 2024, vol. 62, p.39-45

External positions

Stichting Werkgroep Antibioticabeleid (SWAB) voor behandeling SARS-CoV-2 committee

Congress committee, Nederlandse Intensive Care Vereniging (NVIC)

Chair, Health Services and Research & Outcome (HSRO) of the European Society of Intensive Care Medicine (ESICM)

Very old Intensive Care (VIP) study group, part of the HSRO-section of the European Society of Intensive Care Medicine (ESICM)

Nederlandse Vereniging Intensive Care (NVIC) Taskforce infectieuze bedreigingen

Secretary, National Intensive Care Evaluation (NICE) Foundation