Profile photo Denise van Hout

Denise van Hout

Researcher/Postdoc

Strategic program(s):

Biography

Denise van Hout is a medical doctor and epidemiologist working as a post-doctoral researcher at the Julius Center for Health Sciences, UMC Utrecht. She wrote a PhD thesis on infectious diseases epidemiology and is experienced in collaborating with international researchers in large consortia. In her post-doctoral research she uses data-driven to identify and quantify bottlenecks in the initiation and delivery of randomized clinical trials (RCTs), including adaptive platform trials (APTs), both in the Netherlands and in multinational settings. In addition, she is passionate about creating a more efficient and harmonized research landscape for the future and during health emergencies, such as pandemics. With her work she intends to reduce resource waste and improve the speed with which patients get access to innovative treatments.

Recent publications

From rigid to rapid: rethinking clinical trial processes for emergency-ready clinical trials Denise van Hout, Cristina Prat-Aymerich, Karen van Hulst, Jeri Nijland, Oliver A. Cornely, P. Bruijning-Verhagen, Ingvild Bruun Mikalsen, Rebecca Jane Cox, Henrik Dollner, Sanne Hammer, Per Kristian Knudsen, Andre Oberthuer, Vassiliki Papaevangelou, Emmanuel Roilides, Sven Arne Silfverdal, Camilla Tondel, Susanne Woxenius
Clinical Microbiology and Infection, 2026, vol. 32, p.691-695
Considerations raised during the regulatory and ethics review of platform clinical trials in infectious diseases Amos de Jong, Denise van Hout, Janneke Verberk, Marjolein Hensgens, Alike van der Velden, Janneke H. van de Wijgert, Marc Bonten, LP Derde
Contemporary clinical trials communications, 2026, vol. 51
Hurdles for the Delivery of Multinational Randomized Clinical Trials Denise van Hout, Paul Mouncey, David Harrison, Marc Bonten, Lennie Derde, Derek C Angus, Aisha Anjum, Djillali Annane, Janis Best-Lane, Frank Brunkhorst, Maurizio Cecconi, Stephan Ehrmann, Anthony Gordon, Leanne Marie Hays, Esmee Kester, Niamh Mahon, Colin McArthur, Alistair Nichol, Svenja Peters, Sara Pugliese, Kathryn Rowan, Julian Torre-Cisneros, Sebastian Weis,
JAMA network open, 2025, vol. 8
Influenza Infection and Acute Myocardial Infarction Annemarijn R de Boer, Annelies Riezebos-Brilman, Denise van Hout, Maaike S M van Mourik, Lidewij W Rümke, Marieke L A de Hoog, Ilonca Vaartjes, Patricia C J L Bruijning-Verhagen
NEJM evidence, 2024, vol. 3
Comparative genomics of ESBL-producing Escherichia coli (ESBL-Ec) reveals a similar distribution of the 10 most prevalent ESBL-Ec clones and ESBL genes among human community faecal and extra-intestinal infection isolates in the Netherlands (2014-17) T D Verschuuren, D van Hout, S Arredondo-Alonso, A C Fluit, E A Reuland, J Top, A C Schürch, T Bosch, M J M Bonten, J A J W Kluytmans, R J L Willems
The Journal of antimicrobial chemotherapy, 2021, vol. 76, p.901-908
Universal risk assessment upon hospital admission for screening of carriage with multidrug-resistant micro-organisms in a Dutch tertiary care centre Denise van Hout, Patricia C J Bruijning-Verhagen, Hetty Blok, Annet Troelstra, Marc J M Bonten
The journal of Hospital Infection, 2021, vol. 109, p.32-39