Dani Heesterbeek

Assistant Professor

Strategic program(s):

Contact

dheeste2@umcutrecht.nl

Pure profile

Research groups

Bacterial infections & immunity

Research aim

To contribute to development of anti-bacterial immunotherapies by providing a scientific understanding of the mechanisms by which antibodies and complement induce bacterial immune clearance.

Go to group

Recent publications

All publications

Bactericidal membrane attack complex formation initiates at the new pole of E. coli Marije F L van 't Wout, Fabian Hauser, Philippa I P Holzapfel, Bart W Bardoel, Carla J C de Haas, Jaroslaw Jacak, Suzan H M Rooijakkers, Dani A C Heesterbeek
EMBO Reports, 2025, vol. 27, p.533-554

Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens Remy M. Muts, Astrid Hendriks, Josefien W. Hommes, Max L.B. Grönloh, Douwe J. Dijkstra, Carla J.C. de Haas, Piet C. Aerts, Eduard H.T.M. Ebberink, Albert J.R. Heck, Zhen Wang, Haoru Zhuang, Jeroen D.C. Codée, Bas G.J. Surewaard, Dani A.C. Heesterbeek, Nina M. van Sorge, Suzan H.M. Rooijakkers
Cell reports. Medicine, 2025, vol. 6

Pmap-37 Fatemeh Pashaie, Naomi Benne, Philippa I P Holzapfel, Tineke Veenendaal, Floris J Bikker, Dani A C Heesterbeek, Femke Broere, Edwin J A Veldhuizen
Microbial pathogenesis, 2025, vol. 204

Effects of Escherichia coli LPS Structure on Antibacterial and Anti-Endotoxin Activities of Host Defense Peptides Ali Javed, Melanie D. Balhuizen, Arianne Pannekoek, Floris J. Bikker, Dani A.C. Heesterbeek, Henk P. Haagsman, Femke Broere, Markus Weingarth, Edwin J.A. Veldhuizen
Pharmaceuticals, 2023, vol. 16

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin András N. Spaan, Anna Lena Neehus, Emmanuel Laplantine, Frederik Staels, Masato Ogishi, Yoann Seeleuthner, Franck Rapaport, Keenan A. Lacey, Erika Van Nieuwenhove, Maya Chrabieh, David Hum, Mélanie Migaud, Araksya Izmiryan, Lazaro Lorenzo, Tatiana Kochetkov, Dani A.C. Heesterbeek, Bart W. Bardoel, Ashley L. DuMont, Kerry Dobbs, Solenne Chardonnet, Søren Heissel, Timour Baslan, Peng Zhang, Rui Yang, Dusan Bogunovic, Herman F. Wunderink, Pieter Jan A. Haas, Henrik Molina, Griet Van Buggenhout, Stanislas Lyonnet, Luigi D. Notarangelo, Mikko R.J. Seppänen, Robert Weil, Gisela Seminario, Héctor Gomez-Tello, Carine Wouters, Mehrnaz Mesdaghi, Mohammad Shahrooei, Xavier Bossuyt, Erdal Sag, Rezan Topaloglu, Seza Ozen, Helen L. Leavis, Maarten M.J. van Eijk, Liliana Bezrodnik, Lizbeth Blancas Galicia, Alain Hovnanian, Aude Nassif, Brigitte Bader-Meunier, Bénédicte Neven, Isabelle Meyts, Rik Schrijvers, Anne Puel, Jacinta Bustamante, Ivona Aksentijevich, Daniel L. Kastner, Victor J. Torres, Stéphanie Humblet-Baron, Adrian Liston, Laurent Abel, Bertrand Boisson, Jean Laurent Casanova
Science, 2022, vol. 376

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes Dani A.C. Heesterbeek, Remy M. Muts, Vincent P. van Hensbergen, Pieter de Saint Aulaire, Tom Wennekes, Bart W. Bardoel, Nina M. van Sorge, Suzan H.M. Rooijakkers
PLoS Pathogens, 2021, vol. 17