Caroline de Theije

Assistant Professor

Strategic program(s):

Contact

ctheije@umcutrecht.nl

Pure profile

Research groups

Protection and repair of the injured newborn brain

Research aim

Our mission is to unravel the impact of early life adversity, such as perinatal asphyxia and stroke, preterm birth and early life stress on brain development and to design strategies to improve outcome of affected infants, shaping a better future.

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Developmental origins of disease

Research aim

Our laboratory is dedicated to understanding how early life events, such as preterm birth and perinatal complications, influence brain development and long-term outcomes.

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Recent publications

All publications

A systematic scoring system to optimise the testing of neurotherapeutics in models of perinatal brain injury, with an applied case study of human umbilical-cord MSC Cindy Bokobza, Clémence Réda, Syam Nair, David Guenoun, Eridan Rocha-Ferreira, Valérie Faivre, Tifenn Le Charpentier, Cora Nijboer, Caroline de Theije, Sophie Lebon, Joakim Ek, Mohamed Gaeth Hafez, Leslie Schwendimann, Médine Benchouaia, Sophie Lemoine, Giorgia Volpi, Katiuscia Dallaglio, Nicola Pelizzi, Bobbi Fleiss, Juliette Van Steenwinckel, Andrée Delahaye-Duriez, Henrik Hagberg, Pierre Gressens,
Journal of Neuroinflammation, 2025, vol. 23

Osteopontin Preconditioning Improves the Regenerative Effects of Mesenchymal Stem Cells In Vitro but Not Their Therapeutic Efficacy Following Hypoxia-Ischemia in Mice Sara T De Palma, Celine N van Wijk-Eeftink, Lisanne M Baak, Cora H A Nijboer, Caroline G M de Theije
Cells, 2025, vol. 14

Intranasal Wharton's Jelly-Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic-Ischemic Brain Injury in Mice Caroline G M de Theije, Sara T De Palma, Josine E G Vaes, Katiuscia Dallaglio, Giorgia Volpi, Diego Ardigò, Sabine van Rijt, Frank van Bel, Manon J N L Benders, Cora H A Nijboer
Annals of Neurology, 2025, vol. 98, p.1380-1394

Human milk oligosaccharides improve white matter and interneuron development in a double-hit rat model for preterm brain injury Myrna J V Brandt, Juliette Van Steenwinckel, Bobbie-Louise Van Emst, Julia Lohr, Marko Mank, Lidewij Schipper, Louise Harvey, Manon J N L Benders, Caroline G M de Theije
Neuropharmacology, 2025, vol. 276

Hypoxic Preconditioning Enhances the Potential of Mesenchymal Stem Cells to Treat Neonatal Hypoxic-Ischemic Brain Injury Sara T. De Palma, Eva C. Hermans, Tatiana M. Shamorkina, Chloe Trayford, Sabine van Rijt, Albert J.R. Heck, Cora H.A. Nijboer, Caroline G.M. de Theije
Stroke, 2025, vol. 56, p.1872-1882

Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of encephalopathy of prematurity M. J.V. Brandt, C. M. Kosmeijer, E. J.M. Achterberg, C. G.M. de Theije, C. H. Nijboer
Brain, Behavior, and Immunity - Health, 2024, vol. 40