Profile photo Wiepke Cahn

Wiepke Cahn

Full Professor

Strategic program(s):

Biography

Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders and lifestyle psychiatry.

Wiepke Cahn has (co)authored more than 300 papers and book chapters and has been chief editor of the textbooks 'schizophrenia spectrum disorders' and 'lifestyle psychiatry' and is the author of 'focus on the families with psychiatric problems'. Her non-research-based activities consist of treating patients and their families with psychiatric and somatic co-morbidities.

Research Line

Physical health in psychiatric disorders and lifestyle psychiatry.

Key publications

1. de Boer N, Cahn W. Antipsychotic-induced weight gain: Is the weight over? New guidelines needed. Acta Psychiatr Scand. 2022 Sep;146(3):185-189

2. Burin LM, Hahn MK, da Rocha NS, van Amelsvoort T, Bartels-Velthuis AA, Bruggeman R, de Haan L, Schirmbeck F, Simons CJP, van Os J, Cahn W. Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder: Evidence from GROUP, a longitudinal study. Psychiatry Res. 2022 Aug;314:114680. 

3. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.

4. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.

5. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.

 

Strategic program(s):

Contact

Research groups

Innovation in psychiatry

Research aim

Innovation in Psychiatry embraces patient involvement, use different data sources and tools & methods for personalized prediction and treatment. With a holistic approach, we aim to improve the well-being of individuals with mental health problems.

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Recent publications

Genetic susceptibility of cardiometabolic outcomes in schizophrenia spectrum disorders Chenxu Zhao, Bochao Lin, Elnaz Naderi, Sara Moazzen, Tesfa Dejenie Habtewold, Richard Bruggeman, Therese van Amelsvoort, Wiepke Cahn, Lieuwe de Haan, Marieke van der Pluijm, Claudia J.P. Simons, Jim van Os, Wim Veling, Behrooz Z. Alizadeh
Schizophrenia Research, 2026, vol. 292, p.103-115
Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes Javier González-Peñas, Hugo G Schnack, Carmen Rueda Hernández, Covadonga M Díaz-Caneja, Celia de la Fuente Montero, Marta Martín Echave, Alberto Mora, Niels Janssen, Pedro M Gordaliza, Alberto Fernández-Pena, Daniel Martín de Blas, Susana Carmona, Wiepke Cahn, Neeltje E M van Haren, René S Kahn, Hilleke Hulshoff Pol, Celso Arango, Yasser Alemán-Gómez, Joost Janssen
2026
Defining suicidality phenotypes for genetic studies Sarah M.C. Colbert, Eric T. Monson, Ole A. Andreassen, Olatunde Ayinde, Peter B. Barr, Cosmin A. Bejan, Zuriel Ceja, Hilary Coon, Emily DiBlasi, Howard J. Edenberg, Joel Gelernter, Alexander S. Hatoum, Anastasia Izotova, Emma C. Johnson, Erin A. Kaufman, Henry R. Kranzler, Maria Koromina, Kelli Lehto, Woojae Myung, John I. Nurnberger, Alessandro Serretti, Jordan W. Smoller, Murray B. Stein, Clement C. Zai, Annette Erlangsen, Marie Gaine, Lourdes Martorell, Reeteka Sud, Claudio Toma, Tim B. Bigdeli, Nathan A. Kimbrel, Douglas Ruderfer, Anna R. Docherty, J. John Mann, Niamh Mullins, Lea Zillich, Zeynep Yilmaz, Naomi R. Wray, D. Blake Woodside, Stephanie H. Witt, Virginia Willour, Leanne M. Williams, David C. Whiteman, Thomas Werge, Frank Wendt, Myrna M. Weissman, Roel A. Ophoff, René S. Kahn, Wiepke Cahn, Marco P. Boks,
Molecular Psychiatry, 2025, vol. 30, p.6144-6154
Exploring the Interplay between Smoking, Stress, and Negative Affect in Patients with Psychosis Dunja van der Velde, Sanne van der Heijden, Claudia Simons, Therese van Amelsvoort, Marieke van der Pluijm, Behrooz Alizadeh, Wim Veling, Lieuwe de Haan, Wiepke Cahn, Frederike Schirmbeck, Jentien Vermeulen
European Psychiatry, 2025, vol. 69
Structural brain abnormalities and aggression in schizophrenia Jelle Lamsma, Adrian Raine, Seyed M Kia, Wiepke Cahn, Dominic Arold, Nerisa Banaj, Annarita Barone, Katharina Brosch, Rachel Brouwer, Arturo Brunetti, Vince D Calhoun, Qian H Chew, Sunah Choi, Young-Chul Chung, Mariateresa Ciccarelli, Derin Cobia, Sirio Cocozza, Udo Dannlowski, Paola Dazzan, Andrea de Bartolomeis, Marta Di Forti, Alexandre Dumais, Jesse T Edmond, Stefan Ehrlich, Ulrika Evermann, Kira Flinkenflügel, Foivos Georgiadis, David C Glahn, Janik Goltermann, Melissa J Green, Dominik Grotegerd, Amalia Guerrero-Pedraza, Minji Ha, Elliot L Hong, Hilleke Hulshoff Pol, Felice Iasevoli, Stefan Kaiser, Vasily Kaleda, Andriana Karuk, Minah Kim, Tilo Kircher, Matthias Kirschner, Peter Kochunov, Jun Soo Kwon, Irina Lebedeva, Rebekka Lencer, Tiago R Marques, Susanne Meinert, Robin Murray, Igor Nenadić, Dana Nguyen, Godfrey Pearlson, Fabrizio Piras, Edith Pomarol-Clotet, Giuseppe Pontillo, Stéphane Potvin, Adrian Preda, Yann Quidé, Amanda Rodrigue, Kelly Rootes-Murdy, Raymond Salvador, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Frederike Stein, Florian Thomas-Odenthal, Andràs Tikàsz, David Tomecek, Alexander Tomyshev, Mario Tranfa, Uyanga Tsogt, Jessica A Turner, Theo G M van Erp, Neeltje E M van Haren, Jim van Os, Daniela Vecchio, Lei Wang, Adrian Wroblewski, Thomas Nickl-Jockschat
Molecular Psychiatry, 2025, vol. 31, p.2273-2282
Effect of polygenic scores on the relationship between psychosis and cognition Lauren Varney, Krisztina Jedlovszky, Baihan Wang, Stephen Murtough, Marius Cotic, Alvin Richards-Belle, Noushin Saadullah Khani, Robin Lau, Rosemary Abidoph, Andrew McQuillin, Johan H. Thygesen, Matthias Weisbrod, Dan Rujescu, John Powell, Andrew M. McIntosh, Kuang Lin, Cathryn Lewis, Ina Giegling, Marta Di Forti, Maria J. Arranz, Neeltje E.M. van Haren, Wim Veling, Jim van Os, Claudia J.P. Simons, Marieke van der Pluijm, Lieuwe de Haan, Wiepke Cahn, Therese van Amelsvoort, Behrooz Z. Alizadeh, Stephan Bender, Benedicto Crespo-Facorro, Jeremy Hall, Conrad Iyegbe, Eugenia Kravariti, Stephen M. Lawrie, Ignacio Mata, Colm McDonald, Robin M. Murray, Diana Prata, Timothea Toulopoulou, Neeltje E.M. van Haren, Elvira Bramon, ,
Translational Psychiatry, 2025, vol. 15

Fellowships & Awards

  • Move2 (MUVA) project 
  • Tactic project 
  • Lifestyle - A multi-modal lifestyle intervention program in routine clinical care for children with mental disorders.
  • FOCUS
  • MELIA project   
  • Psychosis Prognosis Predictor 
  • Genetic Risk and Outcome of Psychosis (GROUP project) Collaboration between AMC, UMCG en Universiteit van Maastricht and various psychiatric institutions in the Netherlands
  • Topfit project – i.s.m. met sportgeneeskunde
  • GRUMPY or Depressed – i.s.m. de sociale faculteit UU

External positions

voorzitter raad van bestuur - vergaderingen voorzitten en toezichthouden - Socialrun

Raad van Toezicht - voorzitter commissie kwaliteit & veiligheid; lid RvT - GGZBreburg