András Spaan

Associate Professor - medical

Strategic program(s):

Contact

aspaan@umcutrecht.nl

Pure profile

Research groups

Human genetics of host-microbe interactions

Research aim

We study the human genetic and immunological determinants of host-pathogen interactions

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Recent publications

All publications

Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity Tristan J van der Linden, Arnab Chatterjee, Lisette M Scheepmaker, Debajyoti Chakraborty, Somnath Dutta, Bart W Bardoel, András N Spaan
PLoS pathogens, 2026, vol. 22

Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2 Michelle Møhlenberg, Sofie Eg Jørgensen, Renée Marije van der Sluis, Thomas Zillinger, Daniëla Maria Hinke, Anne Kruse Hollensen, Anne Louise Hansen, Pierre Hausfater, Guy Gorochov, Florence Tubach, Jade Ghosn, Cedric Laouenan, Merete Storgaard, Christian Kanstrup Holm, Helen Su, Rebeca Pérez de Diego, Aurora Pujol, Shen Ying Zhang, Qian Zhang, Fernanda Sales Luiz Vianna, Laurent Abel, Aurélie Cobat, Jean Laurent Casanova, Trine H. Mogensen, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, András N. Spaan, Antoine Khalil, David T.P. Buis, Lucas Fleuren, Endry H.T. Lim, Niels van Mourik, Tom Reijnders, Marc van der Valk, , , , , , , , ,
Proceedings of the National Academy of Sciences of the United States of America, 2026, vol. 123

Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2 Lili Hu, Renee M. van der Sluis, Kennith Brian Castelino, Bao Cun Zhang, Andreas Ronit, Thomas Zillinger, Marvin Werner, Sofie Eg Jørgensen, Anne Louise Hansen, Alice Pedersen, Ryo Narita, Line S. Reinert, Bettina Bundgaard, Marie Helleberg, Thomas Benfield, Merete Storgaard, Kristoffer Skaalum Hansen, Jacob Bodilsen, Shen Ying Zhang, Qian Zhang, Mayana Zatz, Joost Wauters, Horst von Bernuth, Donald C. Vinh, Fernanda Sales Luiz Vianna, Diederik van de Beek, Mohammed J. Uddin, K. M.Furkan Uddin, Stuart E. Turvey, Sophie Trouillet-Assant, Pierre Tiberghien, Christian Thorball, Şehime Gülsün Temel, Ahmad Abou Tayoun, Stuart G. Tangye, Ivan Tancevski, Helen C. Su, András N. Spaan, Vassili Soumelis, Pere Soler-Palacín, Andrew L. Snow, Ondrej Slaby, Anna Shcherbina, Mohammad Shahrooei, Mikko R.J. Seppänen, Anna Sediva, Vanessa Sancho-Shimizu, Carlos Rodríguez-Gallego, Igor Resnick, Fulvio Reggiori,
Nature Communications, 2025, vol. 16

The seven enigmas of SARS-CoV-2 Evangelos Andreakos, Lisa Arkin, Paul Bastard, Alexandre Bolze, Alessandro Borghesi, Petter Brodin, Jean-Laurent Casanova, Giorgio Casari, Aurélie Cobat, Beth Drolet, Jacques Fellay, Elena Hsieh, Isabelle Meyts, Trine H Mogensen, Vanessa Sancho-Shimizu, András N Spaan, Helen C Su, Donald C Vinh, Ahmad Yatim, Qian Zhang, Shen-Ying Zhang,
Journal of human immunity, 2025, vol. 1

Novel genotypes, phenotypes, and triggers in humans with OTULIN haploinsufficiency Tristan J van der Linden, Rob J W Arts, Catherine M Biggs, Laleh Habibi, Laura Batlle-Masó, Arjan van Laarhoven, Lisette M Scheepmaker, Pariya Yousefi, Andrea C Gómez-Raccio, Zahra Alizadeh, Catharina M Mulders-Manders, Jaap Ten Oever, Janneke Schuurs-Hoeijmakers, Nasrin Alipour-Olyei, Anne Molitor, Daniela Di Giovanni, Raphael Carapito, Seiamak Bahram, Gisela Seminario, Liliana Bezrodnik, Mana Momenilandi, Mohammad Shahrooei, Jacinta Bustamante, Ivona Aksentijevich, Daniel Kastner, Mohammad R Fazlollahi, Roger Colobran, Stuart E Turvey, Frank L van de Veerdonk, Jean-Laurent Casanova, Bertrand Boisson, Bart W Bardoel, András N Spaan
Journal of human immunity, 2025, vol. 1

Human inborn errors of type I interferon-independent intrinsic immunity in nonleukocytic cells Shen-Ying Zhang, Jean-Laurent Casanova, András N Spaan
Current Opinion in Immunology, 2025, vol. 97

External positions

Visiting Fellow at the St. Giles Laboratory of Human Genetics of Infectious Diseases - Wetenschappelijk samenwerkingsverband MMB UMCU en Casanova Lab Rockefeller University NY - The Rockefeller University