Alexander Yermanos

Assistant Professor

Strategic program(s):

Contact

ayermano@umcutrecht.nl

Pure profile

Research groups

Computational biology & systems immunology

Research aim

We integrate experimental and computational immunology to understand, predict, and engineer adaptive immune recognition. This includes developing software, profiling of immune responses, and designing computationally-guided therapeutics.

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Computational immunology core

Research aim

We bring together bioinformaticians, biostatisticians and mathematical modelers to develop new methodologies to interpret the complex datasets that are being generated by immunologists, and form a bridge between the wet and dry labs and the clinic.

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Recent publications

All publications

Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning Danielle Shlesinger, Viktor Sadilek, Mason Minot, Evangelos Stamkopoulos, Thomas Bikias, Raphael Kuhn, Andreas Agrafiotis, Joseph M. Taft, Alexander Yermanos, Sai T. Reddy
Cell reports methods, 2026, vol. 6

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis Ghazal Shammas, Margot Piccinno, Kristof Egervari, Sylvain Lemeille, Alexandre Mariotte, Federica Maltese, Alessandra Panzeri, Ingrid Wagner, Nicolas Fonta, Tiphaine Furlan, Mario Kreutzfeldt, Ilena Vincenti, Alexander Yermanos, Nicolas Page, Camilla Bellone, Carmen Picon Muñoz, Giovanni Di Liberto, Doron Merkler
Neuron, 2025, vol. 114, p.622-639.e11

Delineating inter- and intra-antibody repertoire evolution with AntibodyForests Daphne van Ginneken, Valentijn Tromp, Lucas Stalder, Tudor Stefan Cotet, Sophie Bakker, Anamay Samant, Sai T. Reddy, Alexander Yermanos
Bioinformatics, 2025, vol. 41

The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells Camilla Panetti, Rahel Daetwyler, Anja Moncsek, Nikolaos Patikas, Andreas Agrafiotis, Adelynn Tang, Francesco Andreata, Valeria Fumagalli, Jean De Lima, Lifen Wen, Carolyn G. King, Ajithkumar Vasanthakumar, Matteo Iannacone, Axel Kallies, Alexander Yermanos, Martin Hemberg, Nicole Joller
Nature immunology, 2025, vol. 26, p.2074–2085

Protein language model pseudolikelihoods capture features of in vivo B cell selection and evolution Daphne van Ginneken, Anamay Samant, Karlis Daga-Krumins, Wiona Glänzer, Andreas Agrafiotis, Evgenios Kladis, Sai T Reddy, Alexander Yermanos
Briefings in bioinformatics, 2025, vol. 26

Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections Andreas Agrafiotis, Raphael Kuhn, Camilla Panetti, Marco Venerito, Hathaichanok Phandee, Lucas Stalder, Danielle Shlesinger, Vittoria Martinolli, Kai-Lin Hong, Daphne van Ginneken, Alessandro Genovese, Nicole Joller, Annette Oxenius, Sai T Reddy, Alexander Yermanos
Journal of immunology (Baltimore, Md. : 1950), 2025, vol. 214, p.2743-2755

External positions

Project Director, Global Immunogenomics - Lead research team and involved in global engagement - Botnar Institute of Immune Engineering