Roger Adan

Full Professor

Strategic program(s):

Biography

Roger Adan was trained as a molecular neurobiologist and received his PhD in 1992 on the regulation of vasopressin and oxytocin gene expression. Since 2002 he is full professor in molecular pharmacology. Via his work on melanocortin receptors he became an expert in molecular and neural pathways underlying feeding behavior, obesity and eating disorders. His lab has a strong multidisciplinary character. A variety of strategies (pharmacogenetics, viral vector technology, in vivo electrophysiology, optogenetics and automated behavioral and physiological analysis) is used to unravel mechanism underlying behavior.  The main focus is on feeding, since this is a natural behavior ideally suited to dissect neural circuits that underlie decision making, anxiety, anhedonia, impulsivity and reward seeking.

Personal fellowships and awards

1: NWO-VIDI grant (016.036.322): Role of neuropeptides in disorders of energy balance
2: ZOnMW-TOP grant (40-00812-98-14093): Shining light on loss of control over substance and food intake
3: co-applicant of 4 granted FP7 programs (Nudge-IT, NeuroFast, Full4Health and I.Family)
4: Recipient of the Rudolf Magnus Research Prize 2003
5: Recipient of the Organon prize for pharmacology 2004

Research line

Neural circuits of feeding and related behaviors

Strategic program(s):

Contact

Research groups

Neural circuit function

Research aim

We aim to unravel the neurobiology underlying eating disorders. This will provide a framework for the development of neurobiology-based therapeutic interventions for diseases like anorexia nervosa.

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Recent publications

Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure Roman Walle, Anna Petitbon, Giulia R. Fois, Christophe Varin, Enrica Montalban, Lola Hardt, Andrea Contini, Maria Florencia Angelo, Mylène Potier, Rodrigue Ortole, Asma Oummadi, Véronique De Smedt-Peyrusse, Roger A. Adan, Bruno Giros, Francis Chaouloff, Guillaume Ferreira, Alban de Kerchove d’Exaerde, Fabien Ducrocq, François Georges, Pierre Trifilieff
Nature Communications, 2024, vol. 15, p.1-16
Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa Zheng An Lu, Alexander Ploner, Andreas Birgegård, Roger Adan, Lars Alfredsson, Tetsuya Ando, Ole Andreassen, Jessica Baker, Andrew Bergen, Wade Berrettini, Andreas Birgegård, Joseph Boden, Ilka Boehm, Vesna Boraska Perica, Harry Brandt, Gerome Breen, Julien Bryois, Katharina Buehren, Cynthia Bulik, Roland Burghardt, Matteo Cassina, Sven Cichon, Jonathan Coleman, Roger Cone, Philippe Courtet, Steven Crawford, Scott Crow, James Crowley, Unna Danner, Oliver Davis, Martina De Zwaan, George Dedoussis, Janiece Desocio, Danielle Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Martien Kas, Bochao Danae Lin, Jurjen Luykx, Roel Ophoff, , Sarah E. Bergen
Schizophrenia bulletin, 2024, vol. 50, p.1255-1265
What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research Laura Di Lodovico, Héloise Hamelin, Lucas DeZorzi, Chloe Tezenas du Montcel, Erik Schéle, Iris Stoltenborg, Roger Adan, Suzanne Dickson, Philip Gorwood, Virginie Tolle, Odile Viltart
Neuroscience Applied, 2024, vol. 3
Fecal microbiota transplantation of patients with anorexia nervosa did not alter flexible behavior in rats Karlijn L. Kooij, Nadia Andrea Andreani, Luna L. van der Gun, Lara Keller, Stefanie Trinh, Benny van der Vijgh, Mieneke Luijendijk, Astrid Dempfle, Beate Herpertz-Dahlmann, Jochen Seitz, Annemarie van Elburg, Unna N. Danner, John Baines, Roger A.H. Adan
International Journal of Eating Disorders, 2024, vol. 57, p.1868-1881
Characterizing and TRAPing a Social Stress-Activated Neuronal Ensemble in the Ventral Tegmental Area Ioannis Koutlas, Louisa E Linders, Stef E van der Starre, Inge G Wolterink-Donselaar, Roger A H Adan, Frank J Meye
Frontiers in Behavioral Neuroscience [E], 2022, vol. 16
Molecular profile and response to energy deficit of leptin-receptor neurons in the lateral hypothalamus N Kakava-Georgiadou, V Drkelic, K M Garner, M C M Luijendijk, O Basak, R A H Adan
Scientific Reports, 2022, vol. 12

Fellowships & Awards

2002: Rol neuropeptiden bij anorexia en vetzucht

External positions

commissielid NCAD - adviezen over proefdieren en proefdiervrije innovaties - RVO-NCAD

gasthoogleraarschap - adviseren molecular neuroscience technologie - Sahlgrenska Academy, university of Gothenburg

wetenschappelijk adviseur - translationeel werk: vertaalslag preklinisch onderzoek naar kliniek (en terug) - Altrecht- Rintveld eetstoornissen kliniek