Publications

A full list of our publications can be found here. Below are some of our key publications.

Key publications

Pyoderma gangrenosum caused by the molecular uncoupling of OTULIN catalytic activity and LUBAC binding Barathram Swaminathan, Hwi M. Gil, Sagar Bhattad, Jyothi Janardhanan, Gerardo Mejía Baltodano, Christine Mariskanish, Shamel Basaria, Joseph M. Choi, Qi Liu, Lisette M. Scheepmaker, Mohamud Mohamed, Bertrand Boisson, Jean-Laurent Casanova, Ivona Aksentijevich, András N. Spaan, Janet G. Markle Nature Immunology
Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency András N. Spaan, Bertrand Boisson, Seth L. Masters. Journal of Experimental Medicine (2025) 222 (5): e20241047
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin Spaan AN, Neehus AL, Laplantine E, Staels F, Ogishi M, Seeleuthner Y, Rapaport F, Lacey KA, Van Nieuwenhove E, Chrabieh M, Hum D, Migaud M, Izmiryan A, Lorenzo L, Kochetkov T, Heesterbeek DAC, Bardoel BW, DuMont AL, Dobbs K, Chardonnet S, Heissel S, Baslan T, Zhang P, Yang R, Bogunovic D, Wunderink HF, Haas PA, Molina H, Van Buggenhout G, Lyonnet S, Notarangelo LD, Sepp.nen MRJ, Weil R, Seminario G, Gomez-Tello H, Wouters C, Mesdaghi M, Shahrooei M, Bossuyt X, Sag E, Topaloglu R, Ozen S, Leavis HL, van Eijk MMJ, Bezrodnik L, Blancas Galicia L, Hovnanian A, Nassif A, Bader-Meunier B, Neven B, Meyts I, Schrijvers R, Puel A, Bustamante J, Aksentijevich I, Kastner DL, Torres VJ, Humblet-Baron S, Liston A, Abel L, Boisson B, Casanova JL. Science . 2022 Jun 17;376(6599)
Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin. Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Lebbink RJ, Haas PA, Henry T, Spaan AN Nat Microbiol . 2018 Jun;3(6):708-717.
Novel genotypes, phenotypes, and triggers in humans with OTULIN haploinsufficiency Tristan J. van der Linden, Rob J.W. Arts, Catherine M. Biggs, Laleh Habibi, Laura Batlle-Masó, Arjan van Laarhoven, Lisette M. Scheepmaker, Pariya Yousefi, Andrea C. Gómez-Raccio, Zahra Alizadeh, Catharina M. Mulders-Manders, Jaap ten Oever, Janneke Schuurs-Hoeijmakers, Nasrin Alipour-Olyei, Anne Molitor, Daniela Di Giovanni, Raphael Carapito, Seiamak Bahram, Gisela Seminario, Liliana Bezrodnik, Mana Momenilandi, Mohammad Shahrooei, Jacinta Bustamante, Ivona Aksentijevich, Daniel L. Kastner, Mohammad Reza Fazlollahi, Roger Colobran, Stuart E. Turvey, Frank L. van de Veerdonk, Jean-Laurent Casanova, Bertrand Boisson, Bart W. Bardoel, András N. Spaan Journal of Human Immunity (JHI)